Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 23; p. 5557
• Main Authors: Ghiulai, Roxana, Roşca, Oana Janina, Antal, Diana Simona, Mioc, Marius, Mioc, Alexandra, Racoviceanu, Roxana, Macaşoi, Ioana, Olariu, Tudor, Dehelean, Cristina, Creţu, Octavian Marius, Voicu, Mirela, Şoica, Codruţa
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.11.2020; MDPI
• Subjects: Animals; Antimicrobial agents; Blood platelets; Cancer therapies; Clinical trials; Clinical Trials as Topic; Collagen; Connective tissue; Drug Evaluation, Preclinical; Extracellular matrix; Fibroblasts; Growth factors; Humans; Infections; Keratin; Metabolites; Molecular Conformation; Molecular Structure; pentacyclic triterpenes; Pentacyclic Triterpenes - chemistry; Pentacyclic Triterpenes - pharmacology; Pentacyclic Triterpenes - therapeutic use; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Review; Skin; Skin - anatomy & histology; Skin Diseases - drug therapy; Skin Diseases - etiology; Skin Diseases - pathology; Skin Physiological Phenomena; Stem cells; Structure-Activity Relationship; tetracyclic triterpenes; Treatment Outcome; Wound healing; Wound Healing - drug effects; pentacyclic triterpenes; tetracyclic triterpenes; wound healing
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules25235557

Wounds are among the most common skin conditions, displaying a large etiological diversity and being characterized by different degrees of severity. Wound healing is a complex process that involves multiple steps such as inflammation, proliferation and maturation and ends with scar formation. Since ancient times, a widely used option for treating skin wounds are plant- based treatments which currently have become the subject of modern pharmaceutical formulations. Triterpenes with tetracyclic and pentacyclic structure are extensively studied for their implication in wound healing as well as to determine their molecular mechanisms of action. The current review aims to summarize the main results of in vitro, in vivo and clinical studies conducted on lupane, ursane, oleanane, dammarane, lanostane and cycloartane type triterpenes as potential wound healing treatments.