Gait variability and biomechanical distinctions in individuals with functional ankle instability: a case–control study based on three-dimensional motion analysis

• Published in: European journal of medical research Vol. 30; no. 1; pp. 493 - 12
• Main Authors: Huang, Dunbing, Zhang, Chen, Song, Wei, Gao, Jiaxin, Tian, Huan, Li, Huaqiang, Ke, Xiaohua, Jiang, Cai, Lin, Zhonghua
• Format: Journal Article
• Language: English
• Published: London BioMed Central 19.06.2025; BioMed Central Ltd; BMC
• Subjects: Adult; Analysis; Ankle; Ankle Injuries - physiopathology; Ankle Joint - physiopathology; Biomechanical Phenomena; Biomedicine; Case-Control Studies; Compensatory mechanisms; Female; Gait - physiology; Gait Analysis - methods; Humans; Infectious Diseases; Injuries; Internal Medicine; Joint Instability - physiopathology; Kinematic alterations; Male; Medicine; Medicine & Public Health; Neurophysiology; Oncology; Postural stability; Rehabilitation strategies; Sensorimotor deficits; Surgery; Young Adult; Sensorimotor deficits; Compensatory mechanisms; Postural stability; Kinematic alterations; Rehabilitation strategies
• ISSN: 2047-783X; 0949-2321; 2047-783X
• DOI: 10.1186/s40001-025-02736-8

Background Ankle sprains, the most common sports injury, often progress to functional ankle instability (FAI), characterized by recurrent instability and neuromuscular deficits. This study utilizes three-dimensional (3D) gait analysis system to quantify lower limb biomechanical alterations in FAI during gait, aiming to identify objective markers for guiding targeted rehabilitation strategies. Study design This case–control study enrolled 31 matched subject pairs (FAI subjects vs. healthy controls) through propensity score matching based on stringent inclusion/exclusion criteria. Demographic data were collected, and functional assessments including the Cumberland Ankle Instability Tool (CAIT), American Orthopedic Foot and Ankle Society (AOFAS) scale, and Visual Analog Scale (VAS) for pain were administered. 3D gait analysis was performed using an infrared motion capture system (BTS SMART-D 400) to quantify biomechanical parameters characterizing FAI-related gait abnormalities. Results In individuals with FAI gait quality is significantly compromised, predominantly evidenced by alterations in pelvic tilt ( P  < 0.05, r  = − 0.67, 95% CI [− 4.75, − 1.95]), as well as deviations in hip ad-abduction ( P  < 0.05, r  = 0.44, 95% CI [− 3.80, − 0.20]). This condition is further characterized by a marked reduction in sagittal plane flexion of the hip joint ( P  < 0.05, r  = − 0.44, 95% CI [0.60, 8.25]) and a decrease in the maximum dorsiflexion of the ankle joint ( P  < 0.05, r  = − 2.56, 95% CI [− 3.76, 0.50]). Additionally, there is an observed increase in the dorsiflexion angle at the forefoot ( P  < 0.05, r  = − 11.04, 95% CI [1.36,4.94]), coupled with a decrease in the dorsiflexion angle at the hindfoot ( P  < 0.05, r  = − 13.16, 95% CI [0.25,4.10]). Conclusions Post-traumatic degradation of peripheral sensorimotor feedback following ankle injury induces central nervous system-mediated motor control reorganization, resulting in altered movement strategies that manifest through modified kinematic coordination patterns across the hip, knee, and ankle joints.