The Pathologic and Molecular Landscape of Esophageal Squamous Cell Carcinogenesis

Esophageal squamous cell carcinoma represents the most common histotype of epithelial neoplasm occurring within esophageal mucosa worldwide. Despite the comprehensive molecular characterization of this entity, to date no significant targeted therapy has been introduced into clinical practice. In thi...

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Published inCancers Vol. 12; no. 8; p. 2160
Main Authors Businello, Gianluca, Parente, Paola, Mastracci, Luca, Pennelli, Gianmaria, Traverso, Giulia, Milione, Massimo, Bellan, Elena, Michelotto, Mauro, Kotsafti, Andromachi, Grillo, Federica, Fassan, Matteo
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 04.08.2020
MDPI
Subjects
Alcohol
Beverages
Carcinogenesis
Cell adhesion & migration
Cell cycle
Cloning
Esophageal cancer
Esophagus
Genes
Genomes
Head & neck cancer
Head and neck
Head and neck carcinoma
Hyperplasia
Mucosa
Mutation
Physiological aspects
Review
Squamous cell carcinoma
Tobacco
Italy
South America
Central Asia
North America
Africa
Online AccessGet full text
ISSN2072-6694
2072-6694
DOI10.3390/cancers12082160

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Summary:Esophageal squamous cell carcinoma represents the most common histotype of epithelial neoplasm occurring within esophageal mucosa worldwide. Despite the comprehensive molecular characterization of this entity, to date no significant targeted therapy has been introduced into clinical practice. In this review, we describe the molecular landscape of esophageal squamous cell carcinoma based on the most recent literature. Moreover, we focus on other rare variants and on the relationship with head and neck squamous cell carcinomas.
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ISSN:2072-6694
2072-6694
DOI:10.3390/cancers12082160