Minimum spanning tree analysis of EEG resting-state functional networks in schizophrenia

• Published in: Scientific reports Vol. 14; no. 1; pp. 10495 - 12
• Main Authors: Becske, Melinda, Marosi, Csilla, Molnár, Hajnalka, Fodor, Zsuzsanna, Farkas, Kinga, Rácz, Frigyes Sámuel, Baradits, Máté, Csukly, Gábor
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.05.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/2649; 692/699/476/1799; Adult; Algorithms; Attention; Brain - diagnostic imaging; Brain - physiopathology; Brain mapping; Case-Control Studies; EEG; Electroencephalography - methods; Female; Functional magnetic resonance imaging; Humanities and Social Sciences; Humans; Magnetic Resonance Imaging - methods; Male; Mental disorders; Middle Aged; multidisciplinary; Nerve Net - diagnostic imaging; Nerve Net - physiopathology; Neural networks; Rest - physiology; Schizophrenia; Schizophrenia - physiopathology; Science; Science (multidisciplinary); Structure-function relationships; Topology; Young Adult
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-61316-8

Schizophrenia is a serious and complex mental disease, known to be associated with various subtle structural and functional deviations in the brain. Recently, increased attention is given to the analysis of brain-wide, global mechanisms, strongly altering the communication of long-distance brain areas in schizophrenia. Data of 32 patients with schizophrenia and 28 matched healthy control subjects were analyzed. Two minutes long 64-channel EEG recordings were registered during resting, eyes closed condition. Average connectivity strength was estimated with Weighted Phase Lag Index (wPLI) in lower frequencies: delta and theta, and Amplitude Envelope Correlation with leakage correction (AEC-c) in higher frequencies: alpha, beta, lower gamma and higher gamma. To analyze functional network topology Minimum Spanning Tree (MST) algorithms were applied. Results show that patients have weaker functional connectivity in delta and alpha frequency bands. Concerning network differences, the result of lower diameter, higher leaf number, and also higher maximum degree and maximum betweenness centrality in patients suggest a star-like, and more random network topology in patients with schizophrenia. Our findings are in accordance with some previous findings based on resting-state EEG (and fMRI) data, suggesting that MST network structure in schizophrenia is biased towards a less optimal, more centralized organization.