Butyryl-cholinesterase is related to muscle mass and strength. A new biomarker to identify elderly subjects at risk of sarcopenia

• Published in: Biomarkers in medicine Vol. 9; no. 7; pp. 669 - 678
• Main Authors: Cacciatore, Francesco, Della-Morte, David, Basile, Claudia, Curcio, Francesco, Liguori, Ilaria, Roselli, Mario, Gargiulo, Gaetano, Galizia, Gianluigi, Bonaduce, Domenico, Abete, Pasquale
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.07.2015
• Subjects: Age; Aged; Aged, 80 and over; Biomarkers; Biomarkers - analysis; Body Mass Index; Butyrylcholinesterase - analysis; Cholinesterases; Cytokines; Diagnosis; Female; Geriatrics; Humans; inflammation; Linear Models; Male; Mortality; Muscle Strength; Muscle, Skeletal - physiology; Musculoskeletal system; Older people; Physiological aspects; Proteins; Sarcopenia; Sarcopenia - diagnosis; Social support; Studies; Values; Italy; inflammation; biomarkers; sarcopenia
• ISSN: 1752-0363; 1752-0371; 1752-0371
• DOI: 10.2217/bmm.15.28

To determine the relationship between Butyryl-cholinesterase (α-glycoprotein synthesized in the liver, b-CHE) and muscle mass and strength. Muscle mass by bioimpedentiometer and muscle strength by grip strength were evaluated in 337 elderly subjects (mean age: 76.2 ± 6.7 years) admitted to comprehensive geriatric assessment. b-CHE levels were lower in sarcopenic than in nonsarcopenic elderly subjects (p < 0.01). Linear regression analysis demonstrated that b-CHE is linearly related with grip strength and muscular mass both in men and women (r = 0.45 and r = 0.33, p < 0.01; r = 0.55 and r = 0.39, p < 0.01; respectively). Multivariate analysis confirms this analysis. b-CHE is related to muscle mass and strength in elderly subjects. Thus, b-CHE may be considered to be a fair biomarker for identifying elderly subjects at risk of sarcopenia.