Clinicopathologic Features and Treatment Characteristics of Congenital Corneal Opacity Infants and Children Aged 3 Years or Less: A Retrospective Single Institution Analysis

• Published in: Medical principles and practice Vol. 29; no. 1; pp. 18 - 24
• Main Authors: Miao, Sen, Lin, Qi, Liu, Yang, Song, Yao-Wen, Zhang, Ying-Nan, Pan, Zhi-Qiang
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2020
• Subjects: Anterior Eye Segment - abnormalities; Anterior Eye Segment - surgery; Cataracts; Child, Preschool; China - epidemiology; Classification; Comorbidity; Congenital Abnormalities - epidemiology; Congenital diseases; Cornea; Corneal Opacity - complications; Corneal Opacity - congenital; Corneal Opacity - epidemiology; Corneal Opacity - pathology; Corneal Opacity - surgery; Defects; Endothelium; Eye Abnormalities - complications; Eye Abnormalities - surgery; Eye Diseases - congenital; Eye Diseases - epidemiology; Eye surgery; Female; Humans; Infant; Iris; Male; Medical diagnosis; Newborn babies; Original Paper; Patients; Retinal detachment; Retrospective Studies; Risk Factors; Treatment Outcome; Ultrasonic imaging; Visual impairment; China; Beijing China; Infants; Congenital corneal opacity; Clinicopathologic features; Diagnosis
• ISSN: 1011-7571; 1423-0151; 1423-0151
• DOI: 10.1159/000501763

Objective: In this retrospective single institution study, we investigated the clinicopathologic features and treatment characteristics of 90 patients with congenital corneal opacities (CCO) (117 eyes) who were 3 years and younger and treated at our hospital. Subject and Methods: We reviewed the clinical data of patients with CCO who presented for the first time for treatment at our hospital between January 1, 2017, and December 31, 2017. CCO were classified using the “STUMPED” (Sclerocornea, Tears in Descement’s membrane, Metabolic, Peters, Endothelial dystrophy and Dermoid) method and confirmed by pathological examination. ­Results: Seventy percent of the patients had unilateral CCO. Iridocorneal adhesions (61 eyes, 52.1%) and cataracts (22 eyes, 18.8%) were the 2 most common ocular abnormalities. Systemic abnormalities were present in 5 patients (5.6%), including growth retardation (4 patients) and congenital brain defects (1 patient). Eighty-five eyes (72.6%) underwent penetrating keratoplasty (PK), and lamellar keratoplasty (LK) was performed in 30 (25.6%) eyes. Forty-seven (95.9%) eyes with Peters anomaly and all 16 eyes with sclerocornea received PK, and all 24 eyes with dermoids were treated with LK. Conclusion: Our study demonstrates that CCO has varied manifestations in infants and young children in China. A thorough medical history, careful clinical examination, and the use of accessory examinations such as ultrasound biomicroscopy are critical for the accurate diagnosis and classification of CCO and to provide guidance on therapeutic choices.