Association of HLA genes with diffuse panbronchiolitis in Chinese patients

• Published in: Respiratory physiology & neurobiology Vol. 157; no. 2; pp. 366 - 373
• Main Authors: She, Jun, Sun, Qingyi, Fan, Lihong, Qin, Huanlong, Bai, Chunxue, Shen, Ce
• Format: Journal Article
• Language: English
• Published: Amsterdarm Elsevier B.V 01.08.2007; Elsevier
• Subjects: Adult; Aged; Alleles; Asian Continental Ancestry Group - ethnology; Biological and medical sciences; Bronchiolitis - drug therapy; Bronchiolitis - genetics; Chinese; Diffuse panbronchiolitis (DPB); Erythromycin - therapeutic use; Female; Fundamental and applied biological sciences. Psychology; Gene Frequency; Genetic Predisposition to Disease; HLA Antigens - genetics; HLA genes; HLA-A11; HLA-A2; HLA-B54; HLA-DRB5010/020; Humans; In Situ Hybridization - methods; Male; Medical Education; Microarray Analysis - methods; Middle Aged; Oligonucleotide microarray; Protein Synthesis Inhibitors - therapeutic use; Pulmonary/Respiratory; Retrospective Studies; Vertebrates: respiratory system; OR (95%CI); HLA-DRB5010/020; DPB; HLA genes; Chinese; HLA-A2; HLA-A11; HLA-B54; HLA; Diffuse panbronchiolitis (DPB); PCR; Oligonucleotide microarray; human leukocyte antigen; diffuse panbronchiolitis; odds ratio (95% confidence interval); polymerase chain reaction; Human; HLA-System; Respiratory system; Vertebrata; Mammalia; Gene
• ISSN: 1569-9048; 1878-1519
• DOI: 10.1016/j.resp.2007.01.018

Diffuse panbronchiolitis (DPB) is a pulmonary disease of unknown etiology that predominantly affects East Asians, particularly Japanese with a prevalence of 0.00028. Research has shown that HLA-B54 and HLA-A11 are positively associated with this disease. HLA-A, -B, and -DR loci were analyzed using an oligonucleotide microarray in both Chinese patients with DPB and normal control subjects. The most marked difference between the patients and the controls was the decreased frequency of HLA-A2 ( p = 0.001, OR = 0.12), which showed a negative association with the disease; however, there was no significant contribution of HLA-B loci. Interestingly, the frequency of HLA-A11 was increased ( p = 0.007, OR = 3.9), in accordance with previous reports on Japanese and Koreans. In addition, the frequency of HLA-DRB5*010/020 slightly increased ( p = 0.049). The HLA-associated genes for DPB are located between the HLA-A and HLA-B loci. Differences in HLA-associated genes may partially explain differences in the incidence of DPB among different populations.