Obesity-Related Changes in Cardiac Structure and Function Among Asian Men and Women

• Published in: Journal of the American College of Cardiology Vol. 69; no. 23; pp. 2876 - 2878
• Main Authors: Lai, Yau-Huei, Liu, Ming-En, Su, Cheng-Huang, Yun, Chun-Ho, Liu, Chia-Yuan, Hou, Charles Jia-Yin, Hu, Kuang-Chun, Hung, Chung-Lieh, Yeh, Hung-I, Lam, Carolyn S.P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.06.2017; Elsevier Limited
• Subjects: Asian people; Blood pressure; Body mass index; Cardiology; Cardiovascular; Cardiovascular disease; Cholesterol; Diabetes; Diabetes mellitus; Echocardiography; Fasting; Gender differences; Glomerular filtration rate; Health risk assessment; Heart diseases; Heart failure; Heart rate; Hypertension; Laboratory testing; Medical screening; Mens health; Multivariate analysis; Muscle contraction; Obesity; Public health; Regression analysis; Smoking; Structure-function relationships; Velocity; Ventricle; Weight control; Womens health; Norway; Taiwan
• ISSN: 0735-1097; 1558-3597; 1558-3597
• DOI: 10.1016/j.jacc.2017.04.016

In the entire cohort (mean age 49.8 ± 10.8 years, 65.2% men, mean BMI 24.3 ± 3.6 kg/m2), higher BMI and larger WC were associated with greater LV mass, left atrial dilatation, lower tissue Doppler early-diastolic mitral annulus relaxation velocity (e′), higher early-diastolic mitral inflow-to-tissue Doppler velocity ratio (E/e′); more pronounced contractile dysfunction in terms of decreased GLS, GCS, and lower torsion after adjusting for age, sex, LVMi, heart rate, biochemical data, active smoking, histories of hypertension, diabetes, or cardiovascular disease (all p < 0.05) (Table 1). Adjusted for age, blood pressure, heart rate, fasting glucose, total cholesterol, high-density lipoprotein cholesterol, estimated glomerular filtration rate, histories of hypertension, diabetes, and active smoking or cardiovascular disease in multivariate analysis.e’ = tissue Doppler early-diastolic mitral annulus relaxation velocity; E = mitral inflow Doppler early-diastolic velocity; GCS = global circumferential strain; GLS = global longitudinal strain; IVS = interventricular septal thickness; LAV (max) = maximum left atrial volume; LVEDV = left ventricular end-diastolic volume; LVEF = left ventricular ejection fraction; M/V = mass-to-volume ratio; RWT = relative wall thickness. BMI, kg/m2 Unadjusted Means p for Trend Adjusted Means p for Trend Multivariate Linear Regression (BMI) Multivariate Linear Regression (Waist Circumference) Group 1 Group 2 Group 3 Group 1 Group 2 Group 3 Beta (SE) p Value Beta (SE) p Value 18.5-22.9 23.0-27.49 >=27.5 18.5-22.9 23.0-27.49 >=27.5 Conventional echocardiography IVS, mm 8.5 ± 1.1 9.2 ± 1.0∗ 9.6 ± 1.0∗† <0.001 8.8 ± 0.5 9.1 ± 0.4∗ 9.3 ± 0.4∗† <0.001 0.25 (0.005) <0.001...