What We Talk About When We Talk About Fat

There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the realization that adipose tissue plays a major role in the regulation of metabolic function. The past few years, in particular, have seen significant changes in the way that we classify ad...

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Bibliographic Details
Published in	Cell Vol. 156; no. 1-2; pp. 20 - 44
Main Authors	Rosen, Evan D., Spiegelman, Bruce M.
Format	Journal Article
Language	English
Published	United States Elsevier Inc 16.01.2014
Subjects	adipocytes Adipocytes - metabolism Adipogenesis adipose tissue Animals Humans Lipid Metabolism metabolic diseases obesity Obesity - metabolism Obesity - pathology
Online Access	Get full text
ISSN	0092-8674 1097-4172 1097-4172
DOI	10.1016/j.cell.2013.12.012

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Abstract	There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the realization that adipose tissue plays a major role in the regulation of metabolic function. The past few years, in particular, have seen significant changes in the way that we classify adipocytes and how we view adipose development and differentiation. We have new perspective on the roles played by adipocytes in a variety of homeostatic processes and on the mechanisms used by adipocytes to communicate with other tissues. Finally, there has been significant progress in understanding how these relationships are altered during metabolic disease and how they might be manipulated to restore metabolic health.
AbstractList	There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the realization that adipose tissue plays a major role in the regulation of metabolic function. The past few years, in particular, have seen significant changes in the way that we classify adipocytes and how we view adipose development and differentiation. We have new perspective on the roles played by adipocytes in a variety of homeostatic processes and on the mechanisms used by adipocytes to communicate with other tissues. Finally, there has been significant progress in understanding how these relationships are altered during metabolic disease and how they might be manipulated to restore metabolic health. There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the realization that adipose tissue plays a major role in the regulation of metabolic function. The past few years in particular have seen significant changes in the way we classify adipocytes, and how we view adipose development and differentiation. We have new perspective on the roles played by adipocytes in a variety of homeostatic processes, and the mechanisms used by adipocytes to communicate with other tissues. Finally, there has been significant progress in understanding how these relationships are altered during metabolic disease, and how they might be manipulated to restore metabolic health. There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the realization that adipose tissue plays a major role in the regulation of metabolic function. The past few years, in particular, have seen significant changes in the way that we classify adipocytes and how we view adipose development and differentiation. We have new perspective on the roles played by adipocytes in a variety of homeostatic processes and on the mechanisms used by adipocytes to communicate with other tissues. Finally, there has been significant progress in understanding how these relationships are altered during metabolic disease and how they might be manipulated to restore metabolic health.There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the realization that adipose tissue plays a major role in the regulation of metabolic function. The past few years, in particular, have seen significant changes in the way that we classify adipocytes and how we view adipose development and differentiation. We have new perspective on the roles played by adipocytes in a variety of homeostatic processes and on the mechanisms used by adipocytes to communicate with other tissues. Finally, there has been significant progress in understanding how these relationships are altered during metabolic disease and how they might be manipulated to restore metabolic health.
Author	Spiegelman, Bruce M. Rosen, Evan D.
AuthorAffiliation	3 Broad Institute of Harvard and MIT, Cambridge, MA, 02142 2 Departments of Genetics and Cell Biology, Harvard Medical School, Boston, MA, 02215 1 Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA, 02215 4 Dept. of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA. 02115
AuthorAffiliation_xml	– name: 1 Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA, 02215 – name: 3 Broad Institute of Harvard and MIT, Cambridge, MA, 02142 – name: 4 Dept. of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA. 02115 – name: 2 Departments of Genetics and Cell Biology, Harvard Medical School, Boston, MA, 02215
Author_xml	– sequence: 1 givenname: Evan D. surname: Rosen fullname: Rosen, Evan D. email: erosen@bidmc.harvard.edu organization: Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA – sequence: 2 givenname: Bruce M. surname: Spiegelman fullname: Spiegelman, Bruce M. email: bruce_spiegelman@dfci.harvard.edu organization: Departments of Genetics and Cell Biology, Harvard Medical School, Boston, MA 02215, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/24439368$$D View this record in MEDLINE/PubMed
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Snippet	There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the realization that adipose tissue plays a major...
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SubjectTerms	adipocytes Adipocytes - metabolism Adipogenesis adipose tissue Animals Humans Lipid Metabolism metabolic diseases obesity Obesity - metabolism Obesity - pathology
Title	What We Talk About When We Talk About Fat
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