What We Talk About When We Talk About Fat

There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the realization that adipose tissue plays a major role in the regulation of metabolic function. The past few years, in particular, have seen significant changes in the way that we classify ad...

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Bibliographic Details
Published inCell Vol. 156; no. 1-2; pp. 20 - 44
Main Authors Rosen, Evan D., Spiegelman, Bruce M.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 16.01.2014
Subjects
adipocytes
Adipocytes - metabolism
Adipogenesis
adipose tissue
Animals
Humans
Lipid Metabolism
metabolic diseases
obesity
Obesity - metabolism
Obesity - pathology
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ISSN0092-8674
1097-4172
1097-4172
DOI10.1016/j.cell.2013.12.012

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Summary:There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the realization that adipose tissue plays a major role in the regulation of metabolic function. The past few years, in particular, have seen significant changes in the way that we classify adipocytes and how we view adipose development and differentiation. We have new perspective on the roles played by adipocytes in a variety of homeostatic processes and on the mechanisms used by adipocytes to communicate with other tissues. Finally, there has been significant progress in understanding how these relationships are altered during metabolic disease and how they might be manipulated to restore metabolic health.
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ISSN:0092-8674
1097-4172
1097-4172
DOI:10.1016/j.cell.2013.12.012