In Praise of Descriptive Science: A Breath of Fresh AIRE

Meyer et al. find that subjects lacking the AIRE gene, critical for self-tolerance in T lymphocytes, show a broad range of autoantibody specificities, which can have extremely high affinities. The data also suggest that some of these autoantibodies can, surprisingly, prevent some types of autoimmuni...

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Bibliographic Details
Published inCell Vol. 166; no. 3; pp. 530 - 531
Main Author Davis, Mark M.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 28.07.2016
Subjects
autoantibodies
Autoantibodies - immunology
autoimmunity
Autoimmunity - immunology
genes
Humans
Immune Tolerance
insulin-dependent diabetes mellitus
Self Tolerance - genetics
T-lymphocytes
T-Lymphocytes - immunology
Thymus Gland
Transcription Factors - genetics
Online AccessGet full text
ISSN0092-8674
1097-4172
DOI10.1016/j.cell.2016.07.018

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Summary:Meyer et al. find that subjects lacking the AIRE gene, critical for self-tolerance in T lymphocytes, show a broad range of autoantibody specificities, which can have extremely high affinities. The data also suggest that some of these autoantibodies can, surprisingly, prevent some types of autoimmunity, particularly type I diabetes. Subjects lacking the AIRE gene, critical for self-tolerance in T lymphocytes, show a remarkably broad range of autoantibody specificities, some of which have much higher affinities than what is typical. The data also suggest that some of these autoantibodies can, surprisingly, prevent some types of autoimmunity, particularly type I diabetes.
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ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2016.07.018