ELATOSIDES A AND B, POTENT INHIBITORS OF ETHANOL ABSORPTION IN RATS FROM THE BARK OF ARALIA ELATA SEEM : THE STRUCTURE-ACTIVITY RELATIONSHIPS OF OLEANOLIC ACID OLIGOGLYCOSIDES

• Published in: Chem. Pharm. Bull Vol. 41; no. 11; pp. 2069 - 2071
• Main Authors: HARADA, Emiko, YAMAHARA, Johji, MURAKAMI, Toshiyuki, MATSUDA, Hisashi, YOSHIKAWA, Masayuki, MURAKAMI, Nobutoshi
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1993; 公益社団法人日本薬学会; Maruzen
• Subjects: Absorption - drug effects; Alcohol Deterrents - chemistry; Alcohol Deterrents - isolation & purification; Alcoholism - drug therapy; Alcoholism and acute alcohol poisoning; Animals; Aralia elata; Biological and medical sciences; elatoside A; elatoside B; Ethanol - antagonists & inhibitors; Ethanol - metabolism; ethanol absorption inhibitory effect; Medical sciences; Oleanolic Acid - chemistry; Oleanolic Acid - isolation & purification; Oleanolic Acid - pharmacology; oleanolic acid oligoglycoside; Plant Extracts - chemistry; Plant Extracts - pharmacology; Rats; Structure-Activity Relationship; Toxicology; Asia; China; Ethanol; Rat; Molecular structure; Pharmacognosy; Alcoholism; Rodentia; Bark; Extract; Medicinal plant; Toxicokinetics; Vertebrata; Chemotherapy; Mammalia; Absorption; Treatment; Folk medicine; Structure activity relation; Dicotyledones; Animal; Angiospermae; Plant origin; Isolation; Spermatophyta; Araliaceae
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.41.2069

By monitoring the inhibitory effect on ethanol absorption in rats, new active saponins named elatosides A and B were isolated from the bark of Aralia elata SEEM. together with elatosides C and D. The structures of elatosides A, B, C, and D were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of several oleanolic acid oligoglycosides on ethanol absorption have been examined and some structure-activity relationships have been found.