Regulatory T cells and asthma

• Published in: Journal of Zhejiang University. B. Science Vol. 19; no. 9; pp. 663 - 673
• Main Authors: Zhao, Sheng-tao, Wang, Chang-zheng
• Format: Journal Article
• Language: English
• Published: Hangzhou Zhejiang University Press 01.09.2018; Springer Nature B.V
• Subjects: Allergens; Antigens, CD - analysis; Apyrase - analysis; Asthma; Asthma - immunology; Biomedical and Life Sciences; Biomedicine; breathing; CD4-positive T-lymphocytes; Cell Differentiation; chronic diseases; Cytokines - metabolism; Glucocorticoids; Helper cells; Humans; Hypersensitivity; Immune response; Immune system; Immunological tolerance; Immunomodulation; Immunoregulation; immunosuppression; inflammation; Inhalation; Leukocytes (eosinophilic); Lymphocyte Transfusion; Lymphocytes; Lymphocytes T; Regulatory mechanisms (biology); Respiration; Respiratory tract; Respiratory tract diseases; Review; synthetic glucocorticoids; T-Lymphocytes, Regulatory - classification; T-Lymphocytes, Regulatory - immunology; 哮喘; R562.25; 白介素10(IL-10); Interleukin 10 (IL-10); Regulatory T cell; 调节性T细胞; IL-35; Transforming growth factor β (TGF-β); 转变生长因子β(TGF-β); Asthma; Regulatory T cell; Asthma; Transforming growth factor β (TGF-β); Interleukin 10 (IL-10); IL-35
• ISSN: 1673-1581; 1862-1783; 1862-1783
• DOI: 10.1631/jzus.B1700346

Asthma is a chronic disease of airway inflammation due to excessive T helper cell type 2 (Th2) response. Present treatment based on inhalation of synthetic glucocorticoids can only control Th2-driven chronic eosinophilic inflammation, but cannot change the immune tolerance of the body to external allergens. Regulatory T cells (Tregs) are the main negative regulatory cells of the immune response. Tregs play a great role in regulating allergic, autoimmune, graft-versus-host responses, and other immune responses. In this review, we will discuss the classification and biological characteristics, the established immunomodulatory mechanisms, and the characteristics of induced differentiation of Tregs. We will also discuss the progress of Tregs in the field of asthma. We believe that further studies on the regulatory mechanisms of Tregs will provide better treatments and control strategies for asthma.