Serum levels of carbohydrate antigen 125 in combination with N-terminal pro-brain natriuretic peptide in patients with acute decompensated heart failure

• Published in: The Korean journal of internal medicine Vol. 34; no. 4; pp. 811 - 818
• Main Authors: Yoon, Jae Yong, Yang, Dong Heon, Cho, Hyun Jun, Kim, Nam Kyun, Kim, Chang-Yeon, Son, Jihyun, Roh, Jae-Hyung, Jang, Se Yong, Bae, Myung Hwan, Lee, Jang Hoon, Park, Hun Sik, Cho, Yongkeun, Chae, Shung Chull
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Association of Internal Medicine 01.07.2019; 대한내과학회
• Subjects: Aged; Aged, 80 and over; Biomarkers - blood; ca-125; CA-125 Antigen - blood; Female; heart failure; Heart Failure - blood; Heart Failure - diagnosis; Heart Failure - mortality; Heart Failure - physiopathology; Humans; Male; Membrane Proteins - blood; Middle Aged; mortality; Natriuretic Peptide, Brain - blood; natriuretic peptides; Original; Peptide Fragments - blood; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Factors; Time Factors; 내과학; Heart failure; CA-125; Mortality; Natriuretic peptides
• ISSN: 1226-3303; 2005-6648; 2005-6648
• DOI: 10.3904/kjim.2017.313

Carbohydrate antigen 125 (CA-125) is an emerging prognostic biomarker for heart failure. We aimed to test the long-term prognostic value of CA-125 in combination with N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with acute decompensated heart failure (ADHF). This observational study included a total of 413 patients (64.1 ± 15.6 yearold, 214 men) with ADHF. All-cause mortality during the 2-year follow-up was investigated for the prognosis. During the follow-up (mean follow-up, 591 ± 233 days), 109 deaths (26.0%) were recorded. In the multivariable analysis model, CA-125 was an independent factor associated with all-cause mortality (log CA-125: hazard ratio, 1.23; 95% confidence interval, 1.02 to 1.48; p = 0.030) together with age, sex, New York Heart Association class, β-blocker, and NT-proBNP. The Kaplan-Meier survival analysis demonstrated that the group with both low marker levels showed the best 2-year survival (87.9%) followed by the group with low NT-proBNP and high CA-125 (76.1%), high NT-proBNP and low CA-125 (64.7%) and high NT-proBNP and high CA-125 levels (54.3%) (p < 0.001). Addition of CA-125 in combination with NT-proBNP and established risk factors further increased the predictive power for mortality in patients with ADHF. CA-125 was an independent factor associated with all-cause mortality in patients with ADHF. Combination of CA-125 with NT-proBNP significantly improved the prediction of mortality in patients with ADHF.