Baseline sputum eosinophil + neutrophil subgroups’ clinical characteristics and longitudinal trajectories for NHLBI Severe Asthma Research Program (SARP 3) cohort

• Published in: Journal of allergy and clinical immunology Vol. 146; no. 1; pp. 222 - 226
• Main Authors: Hastie, Annette T., Mauger, David T., Denlinger, Loren C., Coverstone, Andrea, Castro, Mario, Erzurum, Serpil, Jarjour, Nijar, Levy, Bruce D., Meyers, Deborah A., Moore, Wendy C., Phillips, Brenda, Wenzel, Sally E., Fahy, John V., Israel, Elliot, Bleecker, Eugene R., Crosby-Thompson, Allison, Nettles, Carrie, Cinelli, Angeles, Le, Meghan, Lawrence, Joy, Liu, Donna, Mock, Jenelle, Klaus, Danica, Crisafi, Gina, Smith, Regina, Krings, Jeff, Weaver, Rachel, Nguyen, Daniel, McIntire, Kristin, Baicker-McKee, Sara, Charbit, Annabelle, Trudeau, John, Floerke, Heather, Foster, Susan, Rector, Brian, Yin-Declue, Huiqing, Noel, Dr Patricia, Croxton, Dr Tom, Smith, Dr Robert
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2020
• Subjects: Adult; Aged; Asthma - immunology; Asthma - pathology; Cohort Studies; Eosinophils - immunology; Eosinophils - pathology; Female; Humans; Male; Middle Aged; Neutrophils - immunology; Neutrophils - pathology; Sputum - immunology
• ISSN: 0091-6749; 1097-6825; 1085-8725; 1097-6825
• DOI: 10.1016/j.jaci.2020.01.039

Combined elevated sputum eosinophils+neutrophils in asthma associated with lowest lung function, greater healthcare utilization, and longitudinally, further spirometric loss, implicating cell-cell interactions or overlapping inflammatory pathways while increased eosinophils or neutrophils alone show less effect.