A Case of Renal Metastasis of Urothelial Carcinoma With Trophoblastic Differentiation Successfully Treated With Robot‐Assisted Partial Nephrectomy

• Published in: IJU case reports Vol. 8; no. 5; pp. 480 - 484
• Main Authors: Honda, Seiichiro, Uemura, Koichi, Ito, Hiroki, Muraoka, Erika, Tatenuma, Tomoyuki, Ito, Yusuke, Muraoka, Kentaro, Hasumi, Hisashi, Kawano, Naomi, Yamanaka, Shoji, Makiyama, Kazuhide
• Format: Journal Article
• Language: English
• Published: Australia John Wiley & Sons, Inc 01.09.2025; Wiley
• Subjects: Biomarkers; Bladder cancer; Cancer therapies; Case reports; Chemotherapy; human chorionic gonadotropin; Hydronephrosis; Kidneys; Metastasis; Oncology; partial nephrectomy; Prostate; Robots; Testicular cancer; trophoblastic differentiation; Tumors; Urogenital system; Urological surgery; urothelial carcinoma; urothelial carcinoma; human chorionic gonadotropin; metastasis; partial nephrectomy; trophoblastic differentiation
• ISSN: 2577-171X; 2577-171X
• DOI: 10.1002/iju5.70072

ABSTRACT Introduction There are no previous reports of solitary renal metastases from urothelial carcinoma with trophoblastic differentiation, a rare bladder cancer subtype that is pathologically hCGβ positive. Case Presentation A 77‐year‐old male with urothelial carcinoma with trophoblastic differentiation underwent robot‐assisted radical cystectomy following neoadjuvant chemotherapy. Pathological examination revealed urothelial carcinoma, classified as ypT2b and ypN0 with detection of focal hCGβ positivity. Postoperatively, serum hCGβ levels decreased from 1.6 to < 0.2 mIU/mL. At the 9‐month follow‐up, serum hCGβ was elevated to 20.1 mIU/mL with no recurrence on PET‐CT. Gemcitabine–cisplatin chemotherapy was initiated; however, a solitary renal tumor was detected. Partial nephrectomy confirmed that the tumor was a renal metastasis of bladder cancer. Serum hCGβ levels decreased and remained < 0.2 mIU/mL, even 20 months after partial nephrectomy. Conclusion We report a case of urothelial carcinoma with trophoblastic differentiation and elevated serum hCGβ levels, in which a solitary renal metastasis was successfully resected by robot‐assisted partial nephrectomy.