Capillary leak syndrome induced by neoadjuvant cisplatin and gemcitabine in a patient with bladder cancer

• Published in: Urology case reports Vol. 34; p. 101461
• Main Authors: Massafra, Marco, Passalacqua, Maria Ilenia, Lupo, Giuseppe, Altavilla, Giuseppe, Santarpia, Mariacarmela
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2021; Elsevier
• Subjects: Bladder cancer; Capillary leak syndrome; Gemcitabine; Oncology; Gemcitabine; Bladder cancer; Capillary leak syndrome
• ISSN: 2214-4420; 2214-4420
• DOI: 10.1016/j.eucr.2020.101461

Capillary leak syndrome (CLS) is a rare disorder associated with an increased capillar permeability due to an endothelial damage, causing leakage of plasma and proteins into the interstitial compartment. CLS is characterized by rapidly developing edema, hypotension and hypoproteinemia. We observed CLS in a 54-year-old man affected by muscle-invasive bladder cancer who received neoadjuvant treatment with Cisplatin and Gemcitabine. Treatment with infusion of albumin and increasing corticosteroid doses and diuretics led to a complete regression of all signs and symptoms related to the disorder. Of note, the patient showed an objective complete response to chemotherapy and underwent radical surgery on schedule.