Comparison of Minimally Invasive Surgery with Open Surgery for Remnant Gastric Cancer: A Multi-institutional Cohort Study

• Published in: Annals of surgical oncology Vol. 30; no. 6; pp. 3605 - 3614
• Main Authors: Aoyama, Ryuhei, Tsunoda, Shigeru, Okamura, Ryosuke, Yamashita, Yoshito, Hata, Hiroaki, Kinjo, Yosuke, Miki, Akira, Kanaya, Seiichiro, Yamamoto, Michihiro, Matsuo, Koichi, Manaka, Dai, Tanaka, Eiji, Kawada, Hironori, Kondo, Masato, Itami, Atsushi, Kan, Takatsugu, Kadokawa, Yoshio, Ito, Tetsuo, Hirai, Kenjiro, Hosogi, Hisahiro, Nishigori, Tatsuto, Hisamori, Shigeo, Hoshino, Nobuaki, Hida, Koya, Goto, Yoshihito, Nakayama, Takeo, Obama, Kazutaka
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2023; Springer Nature B.V
• Subjects: Cohort analysis; Cohort Studies; Gastric cancer; Gastrointestinal Oncology; Humans; Laparoscopy; Length of Stay; Medicine; Medicine & Public Health; Minimally invasive surgery; Minimally Invasive Surgical Procedures; Neoplasm Recurrence, Local - surgery; Oncology; Patients; Retinal ganglion cells; Retrospective Studies; Stomach Neoplasms - surgery; Surgery; Surgical Oncology; Survival; Treatment Outcome
• ISSN: 1068-9265; 1534-4681; 1534-4681
• DOI: 10.1245/s10434-023-13232-w

Background Despite growing evidence of the effectiveness of minimally invasive surgery (MIS) for primary gastric cancer, MIS for remnant gastric cancer (RGC) remains controversial due to the rarity of the disease. This study aimed to evaluate the surgical and oncological outcomes of MIS for radical resection of RGC. Patients and Methods Patients with RGC who underwent surgery between 2005 and 2020 at 17 institutions were included, and a propensity score matching analysis was performed to compare the short- and long-term outcomes of MIS with open surgery. Results A total of 327 patients were included in this study and 186 patients were analyzed after matching. The risk ratios for overall and severe complications were 0.76 [95% confidence interval (CI): 0.45, 1.27] and 0.65 (95% CI: 0.32, 1.29), respectively. The MIS group had significantly less blood loss [mean difference (MD), −409 mL; 95% CI: −538, −281] and a shorter hospital stay (MD, −6.5 days; 95% CI: −13.1, 0.1) than the open surgery group. The median follow-up duration of this cohort was 4.6 years, and the 3-year overall survival were 77.9% and 76.2% in the MIS and open surgery groups, respectively [hazard ratio (HR), 0.78; 95% CI: 0.45, 1.36]. The 3-year relapse-free survival were 71.9% and 62.2% in the MIS and open surgery groups, respectively (HR, 0.71; 95% CI: 0.44, 1.16). Conclusions MIS for RGC showed favorable short- and long-term outcomes compared to open surgery. MIS is a promising option for radical surgery for RGC.