Respiratory Viruses and Torque Teno Virus in Adults with Acute Respiratory Infections

• Published in: Intervirology Vol. 58; no. 1; pp. 57 - 68
• Main Authors: Prasetyo, Afiono Agung, Desyardi, Martinus Nuherwan, Tanamas, Jimmy, Suradi, Reviono, Harsini, Kageyama, Seiji, Chikumi, Hiroki, Shimizu, Eiji
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2015
• Subjects: Acute Disease - epidemiology; Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Circoviridae Infections - epidemiology; Circoviridae Infections - virology; Coinfection; DNA Virus Infections - epidemiology; DNA Virus Infections - virology; Gyrovirus - isolation & purification; Human adenovirus; Human coronavirus oc43; Human metapneumovirus; Human rhinovirus; Humans; Indonesia - epidemiology; Influenza A Virus, H3N2 Subtype - isolation & purification; Influenza B virus; Influenza B virus - isolation & purification; Influenza, Human - epidemiology; Influenza, Human - virology; Middle Aged; Molecular Epidemiology; Original Paper; Phylogeny; Respiratory Tract Infections - epidemiology; Respiratory Tract Infections - virology; Rhinovirus - isolation & purification; Seasons; Torque teno virus - isolation & purification; Virus Diseases - epidemiology; Virus Diseases - virology; Young Adult; Indonesia; Torque teno virus; Respiratory virus; Adults
• ISSN: 0300-5526; 1423-0100; 1423-0100
• DOI: 10.1159/000369211

Objective: To define the molecular epidemiology of respiratory viral infections in adult patients. Methods: Nasal and throat swabs were collected from all adult patients with influenza-like illness (ILI), acute respiratory infection (ARI), or severe ARI (SARI) admitted to a tertiary hospital in Surakarta, Indonesia, between March 2010 and April 2011 and analyzed for 19 respiratory viruses and for torque teno virus (TTV) and human gyrovirus (HGyV). Results: Respiratory viruses were detected in 61.3% of the subjects, most of whom had ARI (90.8%, OR = 11.39), were hospitalized (96.9%, OR = 22.31), had asthma exacerbation (90.9%, OR = 8.67), and/or had pneumonia (80%, OR = 4.0). Human rhinovirus (HRV) A43 predominated. Influenza A H3N2, human metapneumovirus (HMPV) subtypes A1 and A2, the influenza B virus, human adenovirus B, and human coronavirus OC43 were also detected. All respiratory viruses were detected in the transition month between the rainy and dry seasons. No mixed respiratory virus infection was found. Coinfections of the influenza A H3N2 virus with TTV, HMPV with TTV, HRV with TTV, and human parainfluenza virus-3 with TTV were found in 4.7, 2.8, 19.8, and 0.9% of the samples, respectively. Conclusions: This study highlights the need to perform routine detection of respiratory viruses in adults hospitalized with ARI, asthma exacerbation, and/or pneumonia.