The impact of advanced maternal age on pregnancy outcome

• Published in: Best practice & research. Clinical obstetrics & gynaecology Vol. 70; pp. 2 - 9
• Main Authors: Attali, Emmanuel, Yogev, Yariv
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.01.2021
• Subjects: Advanced maternal age; Assisted reproductive therapy; Female; Fertility; Humans; Hypertension-related disorders; Intrauterine fetal death; Intrauterine growth restriction; Maternal Age; Pregnancy; Pregnancy Outcome - epidemiology; Pregnancy outcomes; Reproductive Techniques, Assisted; Hypertension-related disorders; Intrauterine growth restriction; Pregnancy outcomes; Intrauterine fetal death; Assisted reproductive therapy; Advanced maternal age
• ISSN: 1521-6934; 1532-1932; 1532-1932
• DOI: 10.1016/j.bpobgyn.2020.06.006

Advanced maternal age is becoming an increasingly relevant issue in high-income developed countries. Lower fertility, greater need for assisted reproductive therapy, and an increase in comorbidities, such as hypertension and diabetes, are some of the reasons for the rise in adverse maternal and fetal outcomes. This chapter reviews and summarizes the recent publications on the impact of advanced maternal age on pregnancy outcomes. •Advanced maternal age (AMA) leads to a decrease in fertility, increased need for ART, and increased in early fetal loss because of the impact on chromosomal and genetic disorders.•Elderly gravidae are in risk for late pregnancy maternal complications, especially hypertension-related conditions and gestational diabetes.•AMA is also related to preterm birth, fetal growth restriction, and stillbirth.