Avoiding misdiagnosis in patients with dyspnea and wheezing: a case report illustrating the clinical implications of fixation error

• Published in: Clinical and molecular allergy CMA Vol. 15; no. 1; p. 3
• Main Authors: Di Marco, Fabiano, Sferrazza Papa, Giuseppe Francesco, Radovanovic, Dejan, Santus, Pierachille
• Format: Journal Article
• Language: English
• Published: London BioMed Central 08.02.2017; BioMed Central Ltd
• Subjects: Allergology; Asthma; Care and treatment; Case Report; Complications and side effects; Diagnosis; Dosage and administration; Fluticasone; Immunology; Medicine; Medicine & Public Health; Molecular Medicine; Pulmonary function tests; Translational Allergy; Wheezing; Tracheal stenosis; Pulmonary function tests; Dyspnea; Fluticasone/formoterol; Asthma
• ISSN: 1476-7961; 1476-7961
• DOI: 10.1186/s12948-017-0060-9

Background Bronchial asthma is a heterogeneous respiratory condition which can be mimicked by a wide range of pathologies including upper airways stenosis. The accurate diagnosis of asthma, as with other conditions, may be influenced by fixation errors, which are common in medicine and occur when a physician concentrates on only one element of a clinical case without considering other relevant aspects. Here we report a challenging case characterized by the contemporaneous presence of a common disease, asthma, together with a rare respiratory disease, idiopathic tracheal stenosis. Case presentation The 56-year-old female patient, a former smoker, was referred to our outpatient clinic for exertional dyspnea and persistent wheezing. There were no other respiratory or systemic symptoms over the past three months, and a psychological component was suspected. Spirometry with flow-volume evaluation and bronchoscopy were the key elements to establish the diagnoses and provide treatments. Once the diagnosis of asthma was confirmed, the combination of the anti-inflammatory corticosteroid fluticasone and the rapid-acting bronchodilator formoterol in a single inhaler effectively controlled the patient’s symptoms, confirming the favorable efficacy and safety profile which are reflected in the recommendations of the international guidelines. Conclusions In this paper we describe the clinical investigations and interventions that eventually confirmed a diagnosis of asthma complicated by an idiopathic tracheal stenosis and led to effective treatment of the patient. Awareness of fixation error may avoid misdiagnosis in patients with respiratory disease and a complicated history at presentation.