Cardiac Structure and Function in Cushing's Syndrome: A Cardiac Magnetic Resonance Imaging Study

• Published in: The journal of clinical endocrinology and metabolism Vol. 99; no. 11; pp. E2144 - E2153
• Main Authors: Kamenický, Peter, Redheuil, Alban, Roux, Charles, Salenave, Sylvie, Kachenoura, Nadjia, Raissouni, Zainab, Macron, Laurent, Guignat, Laurence, Jublanc, Christel, Azarine, Arshid, Brailly, Sylvie, Young, Jacques, Mousseaux, Elie, Chanson, Philippe
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.11.2014; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Adolescent; Adrenocorticotropic hormone; Adult; Atrophy; Body mass index; Cushing syndrome; Cushing Syndrome - pathology; Cushing Syndrome - physiopathology; Echocardiography; Ejection fraction; Female; Gadolinium; Heart; Heart - physiopathology; Hot Topics in Translational Endocrinology; Human health and pathology; Humans; Hypertrophy; Hypertrophy, Left Ventricular - pathology; Hypertrophy, Left Ventricular - physiopathology; Life Sciences; Magnetic Resonance Imaging; Male; Middle Aged; Myocardium - pathology; Nervous system diseases; Pituitary; Skeletal muscle; Stroke Volume - physiology; Structure-function relationships; Ventricle; Young Adult
• ISSN: 0021-972X; 1945-7197; 1945-7197
• DOI: 10.1210/jc.2014-1783

Patients with Cushing's syndrome have left ventricular (LV) hypertrophy and dysfunction on echocardiography, but echo-based measurements may have limited accuracy in obese patients. No data are available on right ventricular (RV) and left atrial (LA) size and function in these patients.Objectives:The objective of the study was to evaluate LV, RV, and LA structure and function in patients with Cushing's syndrome by means of cardiac magnetic resonance, currently the reference modality in assessment of cardiac geometry and function.Methods:Eighteen patients with active Cushing's syndrome and 18 volunteers matched for age, sex, and body mass index were studied by cardiac magnetic resonance. The imaging was repeated in the patients 6 months (range 2–12 mo) after the treatment of hypercortisolism.Results:Compared with controls, patients with Cushing's syndrome had lower LV, RV, and LA ejection fractions (P < .001 for all) and increased end-diastolic LV segmental thickness (P < .001). Treatment of hypercortisolism was associated with an improvement in ventricular and atrial systolic performance, as reflected by a 15% increase in the LV ejection fraction (P = .029), a 45% increase in the LA ejection fraction (P < .001), and an 11% increase in the RV ejection fraction (P = NS). After treatment, the LV mass index and end-diastolic LV mass to volume ratio decreased by 17% (P < .001) and 10% (P = .002), respectively. None of the patients had late gadolinium myocardial enhancement.Conclusion:Cushing's syndrome is associated with subclinical biventricular and LA systolic dysfunctions that are reversible after treatment. Despite skeletal muscle atrophy, Cushing's syndrome patients have an increased LV mass, reversible upon correction of hypercortisolism.