Vitamin D3 up-regulated protein 1 controls the priming phase of liver regeneration

• Published in: Journal of veterinary science (Suwŏn-si, Korea) Vol. 14; no. 3; pp. 257 - 262
• Main Authors: Kwon, H.J., Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Republic of Korea, Hong, S.K., Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Republic of Korea, Yoon, W.K., Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Republic of Korea, Nam, K.H., Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Republic of Korea, Choi, I.P., Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea, Kim, D.Y., Seoul National University, Seoul, Republic of Korea, Kim, H.C., Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Republic of Korea, Won, Y.S., Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Republic of Korea
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한수의학회 2013; The Korean Society of Veterinary Science
• Subjects: Animals; Blotting, Western; c-jun-N-terminal kinase, NF-kB, partial hepatechtomy; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Proliferation; Gene Expression Regulation; Hepatectomy; Hepatocytes - cytology; Hepatocytes - physiology; JNK Mitogen-Activated Protein Kinases - genetics; JNK Mitogen-Activated Protein Kinases - metabolism; Liver - physiology; Male; Mice, Knockout; NF-kappa B - genetics; NF-kappa B - metabolism; Original; Polymerase Chain Reaction; Regeneration; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Thioredoxins - genetics; Thioredoxins - metabolism; VITAMIN D; VITAMINA D; VITAMINE D; 수의학; partial hepatectomy; NF-κB; signal transducer and activator of transcription 3; c-Jun-N-terminal kinase; Vitamin D3 up-regulated protein 1
• ISSN: 1229-845X; 1976-555X; 1976-555X
• DOI: 10.4142/jvs.2013.14.3.257

Vitamin D3 up-regulated protein 1 is a potent growth suppressor that inhibits tumor cell proliferation and cell cycle progression when overexpressed. In a previous study, we showed that VDUP1 knockout mice exhibited accelerated liver regeneration because such animals could effectively control the expression of cell cycle regulators that drive the G1-to-S phase progression.