Spike-timing dependent plasticity partially compensates for neural delays in a multi-layered network of motion-sensitive neurons

• Published in: PLoS computational biology Vol. 19; no. 9; p. e1011457
• Main Authors: Sexton, Charlie M., Burkitt, Anthony N., Hogendoorn, Hinze
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 06.09.2023; Public Library of Science (PLoS)
• Subjects: Analysis; Biology and Life Sciences; Brain; Computer and Information Sciences; Convergence; Firing pattern; Information processing; Methods; Motion detection; Multilayers; Neurons; Neurophysiology; Neuroplasticity; Normal distribution; Object motion; Physical Sciences; Plastic properties; Plasticity; Real time; Receptive field; Representations; Social Sciences; Velocity; Visual system; France
• ISSN: 1553-7358; 1553-734X; 1553-7358
• DOI: 10.1371/journal.pcbi.1011457

The ability of the brain to represent the external world in real-time is impacted by the fact that neural processing takes time. Because neural delays accumulate as information progresses through the visual system, representations encoded at each hierarchical level are based upon input that is progressively outdated with respect to the external world. This ‘representational lag’ is particularly relevant to the task of localizing a moving object–because the object’s location changes with time, neural representations of its location potentially lag behind its true location. Converging evidence suggests that the brain has evolved mechanisms that allow it to compensate for its inherent delays by extrapolating the position of moving objects along their trajectory. We have previously shown how spike-timing dependent plasticity (STDP) can achieve motion extrapolation in a two-layer, feedforward network of velocity-tuned neurons, by shifting the receptive fields of second layer neurons in the opposite direction to a moving stimulus. The current study extends this work by implementing two important changes to the network to bring it more into line with biology: we expanded the network to multiple layers to reflect the depth of the visual hierarchy, and we implemented more realistic synaptic time-courses. We investigate the accumulation of STDP-driven receptive field shifts across several layers, observing a velocity-dependent reduction in representational lag. These results highlight the role of STDP, operating purely along the feedforward pathway, as a developmental strategy for delay compensation.