Asian Consensus Guidelines for the Diagnosis and Management of Gastrointestinal Stromal Tumor

• Published in: Cancer research and treatment Vol. 48; no. 4; pp. 1155 - 1166
• Main Authors: Koo, Dong-Hoe, Ryu, Min-Hee, Kim, Kyoung-Mee, Yang, Han-Kwang, Sawaki, Akira, Hirota, Seiichi, Zheng, Jie, Zhang, Bo, Tzen, Chin-Yuan, Yeh, Chun-Nan, Nishida, Toshirou, Shen, Lin, Chen, Li-Tzong, Kang, Yoon-Koo
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Cancer Association 01.10.2016; 대한암학회
• Subjects: Asian People - genetics; China; Consensus; Disease Management; Gastrointestinal Stromal Tumors - diagnosis; Gastrointestinal Stromal Tumors - pathology; Gastrointestinal Stromal Tumors - therapy; Guidelines as Topic; Humans; Molecular Targeted Therapy; Republic of Korea; Special; Taiwan; 의약학; China; Republic of Korea; Taiwan; Regorafenib; Guideline; Gastrointestinal stromal tumors; Sunitinib; Imatinib mesylate
• ISSN: 1598-2998; 2005-9256; 2005-9256
• DOI: 10.4143/crt.2016.187

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors originating in the gastrointestinal tract. With the introduction of molecular-targeted therapy for GISTs which has yielded remarkable outcomes, these tumors have become a model of multidisciplinary oncological treatment. Although Western clinical guidelines are available for GISTs, such as those published by the National Comprehensive Cancer Network (NCCN) and the European Society of Medical Oncology (ESMO), the clinical situations in Asian countries are different from those in Western countries in terms of diagnostic methods, surgical approach, and availability of new targeted agents. Accordingly, we have reviewed current versions of several GIST guidelines published by Asian countries (Japan, Korea, China, and Taiwan) and the NCCN and ESMO and discussed the areas of dissensus. We here present the first version of the Asian GIST consensus guidelines that were prepared through a series of meetings involving multidisciplinary experts in the four countries. These guidelines provide an optimal approach to the diagnosis and management of GIST patients in Asian countries.