Assessment of atrial electromechanical delay in patients with polycystic ovary syndrome in both lean and obese subjects

• Published in: The journal of obstetrics and gynaecology research Vol. 40; no. 4; pp. 1059 - 1066
• Main Authors: Taşolar, Hakan, Mete, Türkan, Ballı, Mehmet, Altun, Burak, Çetin, Mustafa, Yüce, Tuncay, Taşolar, Sevgi, Otlu, Ömür, Bayramoğlu, Adil, Pekdemir, Hasan
• Format: Journal Article
• Language: English
• Published: Australia Blackwell Publishing Ltd 01.04.2014; Wiley Subscription Services, Inc
• Subjects: Adolescent; Adult; atrial electromechanical delay; atrial fibrillation; Atrial Fibrillation - epidemiology; Atrial Fibrillation - etiology; Body Mass Index; Conduction; Cross-Sectional Studies; Doppler effect; Female; Homeostasis; Humans; Insulin resistance; left ventricular diastolic dysfunction; Obesity; Obesity - complications; Ovaries; Polycystic ovary syndrome; Polycystic Ovary Syndrome - complications; Polycystic Ovary Syndrome - physiopathology; Population studies; Risk Factors; Turkey - epidemiology; Young Adult; Turkey; atrial electromechanical delay; atrial fibrillation; left ventricular diastolic dysfunction; insulin resistance; obesity; polycystic ovary syndrome
• ISSN: 1341-8076; 1447-0756; 1447-0756
• DOI: 10.1111/jog.12308

Aim Even though polycystic ovary syndrome (PCOS) is characterized by increased inflammatory activity and insulin resistance, there is no clinical data about whether risk of atrial fibrillation are increased in these patients. We aimed to evaluate atrial conduction parameters predicting atrial involvement in this patient group. Methods The study population comprised 50 women 18–40 years of age who had been diagnosed with PCOS. The patients were divided into two groups: lean women (L‐PCOS) with a body mass index (BMI) under 25 kg/m2 and obese women (O‐PCOS) with a BMI greater than 30 kg/m2. Twenty‐five age‐matched lean healthy women were enrolled voluntarily as the control group. Difference between maximum and minimum P‐wave duration was calculated and was defined as P‐wave dispersion (Pd). Inter‐ and intra‐atrial electromechanical delays (inter‐AED, intra‐AED, respectively) were measured with tissue Doppler imaging. Results Inter‐ and intra‐AED parameters were higher in the L‐PCOS group when compared with control subjects (anova, P = 0.004 and P = 0.013, respectively), and were also significantly higher in the O‐PCOS group compared with other groups (anova, P < 0.001 for both). The regression analyses indicated that Homeostasis Model of Assessment – Insulin Resistance (HOMA‐IR) (β = 0.603, P < 0.001) and BMI (β = 0.379, P < 0.001) were the independent predictors of inter‐AED, HOMA‐IR (β = 0.835, P < 0.001) was an independent predictor of intra‐AED, and BMI (β = 0.457, P = 0.006) and the left atrial diameter (β = 0.350, P < 0.034) were independent predictors of Pd. Conclusion Consequently, our findings provide data regarding prolonged atrial conduction parameters in PCOS patients, especially when accompanied by obesity.