Exploring neuroimaging-genetic co-alteration features of auditory verbal hallucinations in different subjects for the establishment of a predictive model

• Published in: Chinese medical journal Vol. 132; no. 17; pp. 2137 - 2140
• Main Authors: Cheng, Lang-Lang, Wang, Guo-Wei, Zhang, Yan-Chi, Li, Gong-Ying, Tian, Hong-Jun, Wang, Li-Na, Sun, Xiu-Hai, Zhou, Chun-Hua, Zhuo, Chuan-Jun
• Format: Journal Article
• Language: English
• Published: China Lippincott Williams & Wilkins Ovid Technologies 05.09.2019; Department of Psychiatry, Jining Medical University, Jining, Shandong 272191, China; Department of Psychiatric Neuroimaging, Genetic and Comorbidity Laboratory, Tianjin Mental Health Centre, Tianjin Anding Hospital, Tianjin 300222, China; Department of Psychiatric-Neuro-Imaging-Genetics Laboratory(PNG-Lab), Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 325000, China%Department of Psychiatry, Linyi Mental Health Centre, Linyi, Shandong 271000, China%Department of Psychiatry, Sixth Hospital of Changchun City, Changchun, Jilin 134000, China%Department of Psychiatry, Jining Medical University, Jining, Shandong 272191, China%Department of Psychiatric Neuroimaging, Genetic and Comorbidity Laboratory, Tianjin Mental Health Centre, Tianjin Anding Hospital, Tianjin 300222, China%Department of Neurology, Zoucheng People's Hospital, Jining Medical University Affiliated Zoucheng People's Hospital, Zoucheng, Shandong 273500, China%Department of Pharmacy, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China%Department of Psychiatric-Neuro-Imaging-Genetics Laboratory(PNG-Lab), Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 325000, China; Wolters Kluwer Health; Wolters Kluwer
• Subjects: Brain research; Clinical outcomes; Correspondence; Genes; Genomics; Hallucinations; Hallucinations - diagnostic imaging; Humans; Machine learning; Medical diagnosis; Medical imaging; Mental disorders; Models, Theoretical; Neuroimaging - methods; Neurosciences; Pattern recognition; Post traumatic stress disorder; Schizophrenia; @@
• ISSN: 0366-6999; 2542-5641; 2542-5641
• DOI: 10.1097/CM9.0000000000000385

[...]a means to facilitate early, precise diagnosis and treatment is urgently needed. According to EEG-based studies, healthy individuals with AHVs are more likely to perform abnormal self-generated vocalization. Findings of such research support the use of pattern recognition to establish a predictive model for AVH development in individuals with different mental disorders. [...]several important discoveries have been made in AVH-related research in the past 2 years. See PDF] The second novel aspect of the proposed pathway is the performance of a large cohort study with a 2-year follow-up period from the first AVH episode, involving the combined use of machine learning, genomic, and brain connectome methods, as well as consideration of subjects’ sociodemographic characteristics and treatment outcomes, to establish a model for early diagnosis and treatment outcome prediction in different subject groups.