Food-derived serotonergic modulators: effects on mood and cognition

• Published in: Nutrition research reviews Vol. 26; no. 2; pp. 223 - 234
• Main Authors: Hulsken, Sjoerd, Märtin, Antje, Mohajeri, M. Hasan, Homberg, Judith Regina
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.12.2013
• Subjects: adverse effects; Affect - drug effects; amine oxidase (flavin-containing); Animals; Antidepressive Agents, Second-Generation - blood; Antidepressive Agents, Second-Generation - pharmacology; bananas; brain; Brain - drug effects; Brain - metabolism; chickens; cognition; Cognition & reasoning; Cognition - drug effects; Diet; drugs; Emotions; Food; foods; grains; Humans; mechanism of action; Mode of action; Monoamine Oxidase Inhibitors - blood; Monoamine Oxidase Inhibitors - pharmacology; Musa; Nutrition research; nuts; Plant extracts; Plant Extracts - blood; Plant Extracts - pharmacology; rodents; Serotonin; Serotonin - metabolism; Serotonin Agents - blood; Serotonin Agents - pharmacology; Side effects; soybeans; Thunnus; tryptophan; Tryptophan - blood; Tryptophan - pharmacology; tuna; Therapy; Monoamine reuptake; Serotonin levels; Tryptophan; Cognition; Emotion; Food
• ISSN: 0954-4224; 1475-2700; 1475-2700
• DOI: 10.1017/S0954422413000164

The most frequently described drugs in the treatment of mood disorders are selective serotonin reuptake and monoamine oxidase (MAO) inhibitors, enhancing serotonin levels in the brain. However, side-effects have been reported for these drugs. Because serotonin levels in the brain are dependent on the availability of the food-derived precursor tryptophan, foods such as chicken, soyabeans, cereals, tuna, nuts and bananas may serve as an alternative to improve mood and cognition. Here we discuss the effects of high- or low-tryptophan-containing food, as well as plant extracts with a modest monoamine reuptake and MAO-A inhibition functional profile, on mood and cognition in healthy and vulnerable human subjects and rodents. Together the studies suggest that there is an inverted U-shaped curve for plasma tryptophan levels, with low and too high tryptophan levels impairing cognition, and moderate to high tryptophan levels improving cognition. This relationship is found for both healthy and vulnerable subjects. Whereas this relationship may also exist for mood, the inverted U-shaped curve for plasma tryptophan levels and mood may be based on different tryptophan concentrations in healthy v. vulnerable individuals. Animal studies are emerging and allow further understanding of effects and the mode of action of food-derived serotonergic components on mood, cognition and mechanisms. Ultimately, insight into the concentrations of tryptophan and other serotonergic components in food having beneficial effects on mood and cognition in healthy, but particularly vulnerable, subjects may support well-being in our highly demanding society.