Antimicrobial resistance, mechanisms and its clinical significance

• Published in: Disease-a-month Vol. 66; no. 6; p. 100971
• Main Authors: Abushaheen, Manar Ali, Muzaheed, Fatani, Amal Jamil, Alosaimi, Mohammed, Mansy, Wael, George, Merin, Acharya, Sadananda, Rathod, Sanjay, Divakar, Darshan Devang, Jhugroo, Chitra, Vellappally, Sajith, Khan, Aftab Ahmed, Shaik, Jilani, Jhugroo, Poojdev
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2020
• Subjects: Antibiotics; Antimicrobial resistance (AMR); Internal Medicine; Mechanisms of antimicrobial action; Antibiotics; Antimicrobial resistance (AMR); Mechanisms of antimicrobial action
• ISSN: 0011-5029; 1557-8194; 1557-8194
• DOI: 10.1016/j.disamonth.2020.100971

Antimicrobial agents play a key role in controlling and curing infectious disease. Soon after the discovery of the first antibiotic, the challenge of antibiotic resistance commenced. Antimicrobial agents use different mechanisms against bacteria to prevent their pathogenesis and they can be classified as bactericidal or bacteriostatic. Antibiotics are one of the antimicrobial agents which has several classes, each with different targets. Consequently, bacteria are endlessly using methods to overcome the effectivity of the antibiotics by using distinct types of mechanisms. Comprehending the mechanisms of resistance is vital for better understanding and to continue use of current antibiotics. Which also helps to formulate synthetic antimicrobials to overcome the current mechanism of resistance. Also, encourage in prudent use and misuse of antimicrobial agents. Thus, decline in treatment costs and in the rate of morbidity and mortality. This review will be concentrating on the mechanism of actions of several antibiotics and how bacteria develop resistance to them, as well as the method of acquiring the resistance in several bacteria and how can a strain be resistant to several types of antibiotics. This review also analyzes the prevalence, major clinical implications, clinical causes of antibiotic resistance. Further, it evaluates the global burden of antimicrobial resistance, identifies various challenges and strategies in addressing the issue. Finally, put forward certain recommendations to prevent the spread and reduce the rate of resistance growth.