Spinal epidural lipomatosis is a previously unrecognized manifestation of metabolic syndrome

• Published in: The spine journal Vol. 19; no. 3; pp. 493 - 500
• Main Authors: Ishihara, Shinichi, Fujita, Nobuyuki, Azuma, Koichiro, Michikawa, Takehiro, Yagi, Mitsuru, Tsuji, Takashi, Takayama, Michiyo, Matsumoto, Hideo, Nakamura, Masaya, Matsumoto, Morio, Watanabe, Kota
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2019
• Subjects: Adult; Body Mass Index; Epidural fat; Epidural Space - diagnostic imaging; Epidural Space - pathology; Female; Humans; Lipomatosis - epidemiology; Lumbosacral Region - diagnostic imaging; Lumbosacral Region - pathology; Magnetic Resonance Imaging; Male; Medical checkups; Metabolic syndrome; Metabolic Syndrome - epidemiology; Middle Aged; Obesity; Spinal epidural lipomatosis; Tomography, X-Ray Computed; Visceral fat area; Body mass index; Obesity; Spinal epidural lipomatosis; Epidural fat; Visceral fat area; Metabolic syndrome; Medical checkups
• ISSN: 1529-9430; 1878-1632; 1878-1632
• DOI: 10.1016/j.spinee.2018.07.022

Spinal epidural lipomatosis (SEL) is a condition in which excess lumbar epidural fat (EF) deposition often leads to compression of the cauda equina or nerve root. Although SEL is often observed in obese adults, no systematic research investigating the potential association between SEL and metabolic syndrome has been conducted. To elucidate potential association between SEL and metabolic syndrome. An observational study used data of a medical checkup. We retrospectively reviewed data from consecutive subjects undergoing medical checkups. A total of 324 subjects (174 men and 150 women) were enrolled in this study. The correlation of EF accumulation with demographic data and metabolic-related factors was evaluated. The degree of EF accumulation was evaluated based on the axial views of lumbar magnetic resonance imaging. Visceral and subcutaneous fat areas were measured at the navel level using abdominal computed tomography. Metabolic syndrome was diagnosed according to the criteria of the Japanese Society of Internal Medicine. The correlation of SEL with metabolic syndrome and metabolic-related conditions was statistically evaluated. The degree of EF accumulation demonstrated a significant correlation to body mass index, abdominal circumference, and visceral fat area. However, age, body fat percentage, and subcutaneous fat area showed no correlation with the degree of EF accumulation. Logistic regression analysis revealed that metabolic syndrome (odds ratio [OR]=3.8, 95% confidence interval [CI]=1.5–9.6) was significantly associated with SEL. Among the diagnostic criteria for metabolic syndrome, visceral fat area ≥100 cm2 (OR=4.8, 95% CI=1.5–15.3) and hypertension (OR=3.5, 95% CI=1.1–11.8) were observed to be independently associated with SEL. This is the first study to demonstrate that metabolic syndrome is associated with SEL in a relatively large, unbiased population. Our data suggest that metabolic-related conditions are potentially related to EF deposition and that SEL could be a previously unrecognized manifestation of metabolic syndrome.