Clinical value of cortical bursting in preterm infants with intraventricular haemorrhage

• Published in: Early human development Vol. 184; p. 105840
• Main Authors: Koskela, Tuomas, Meek, Judith, Huertas-Ceballos, Angela, Kendall, Giles S., Whitehead, Kimberley
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.09.2023
• Subjects: Advanced Basic Science; Delta brushes; Developmental trajectory; IVH; Morphine; Neonatal and Perinatal Medicine; Spontaneous activity transients; Developmental trajectory; Spontaneous activity transients; Morphine; IVH; Delta brushes
• ISSN: 0378-3782; 1872-6232; 1872-6232
• DOI: 10.1016/j.earlhumdev.2023.105840

In healthy preterm infants, cortical burst rate and temporal dynamics predict important measures such as brain growth. We hypothesised that in preterm infants with germinal matrix-intraventricular haemorrhage (GM-IVH), cortical bursting could provide prognostic information. We determined how cortical bursting was influenced by the injury, and whether this was related to developmental outcome. Single-centre retrospective cohort study at University College London Hospitals, UK. 33 infants with GM-IVH ≥ grade II (median gestational age: 25 weeks). We identified 47 EEGs acquired between 24 and 40 weeks corrected gestational age as part of routine clinical care. In a subset of 33 EEGs from 25 infants with asymmetric injury, we used the least-affected hemisphere as an internal comparison. We tested whether cortical burst rate predicted survival without severe impairment (median 2 years follow-up). In asymmetric injury, cortical burst rate was lower over the worst- than least-affected hemisphere, and bursts over the worst-affected hemisphere were less likely to immediately follow bursts over the least-affected hemisphere than vice versa. Overall, burst rate was lower in cases of GM-IVH with parenchymal involvement, relative to milder structural injury grades. Higher burst rate modestly predicted survival without severe language (AUC 0.673) or motor impairment (AUC 0.667), which was partly mediated by structural injury grade. Cortical bursting can index the functional injury after GM-IVH: perturbed burst initiation (rate) and propagation (inter-hemispheric dynamics) likely reflect associated grey matter and white matter damage. Higher cortical burst rate is reassuring for a positive outcome. •In asymmetric injury, burst rate is lower over the worst-affected hemisphere.•Asymmetric GM-IVH unbalances inter-hemispheric burst dynamics.•Overall, burst rate is lower in cases of GM-IVH with parenchymal involvement.•Higher burst rate predicts positive outcome, which is mediated by injury grade.