IFN-α/IFN-λ responses to respiratory viruses in paediatric asthma

The letter by S. Baraldo and co-workers raises some interesting points. It is correct that we cannot exclude the possibility that interferon upregulation during the acute phase in asthmatics, though existent, is suboptimal if compared to healthy subjects. It is also possible that there might be diff...

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Published inThe European respiratory journal Vol. 49; no. 3; p. 1700006
Main Authors Bergauer, Annika, Sopel, Nina, Kroß, Bettina, Vuorinen, Tytti, Xepapadaki, Paraskevi, Weiss, Scott T., Blau, Ashley, Sharma, Himanshu, Kraus, Cornelia, Springel, Rebekka, Rauh, Manfred, Mittler, Susanne, Graser, Anna, Zimmermann, Theodor, Melichar, Volker O., Kiefer, Alexander, Kowalski, Marek L., Sobanska, Anna, Jartti, Tuomas, Lukkarinen, Heikki, Papadopoulos, Nikolaos G., Finotto, Susetta
Format Journal Article
LanguageEnglish
Published England European Respiratory Society Journals Ltd 01.03.2017
Subjects
Asthma
Child
Humans
Interferon
Interferon-alpha
Viruses
Workers
Online AccessGet full text
ISSN0903-1936
1399-3003
1399-3003
DOI10.1183/13993003.00006-2017

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Summary:The letter by S. Baraldo and co-workers raises some interesting points. It is correct that we cannot exclude the possibility that interferon upregulation during the acute phase in asthmatics, though existent, is suboptimal if compared to healthy subjects. It is also possible that there might be differences in kinetics, with peak expression reached at different time points in different groups. What we have established is that interferon deficiency in asthma is more complex than a simple on/off mechanism.
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ISSN:0903-1936
1399-3003
1399-3003
DOI:10.1183/13993003.00006-2017