Multidrug-resistant Neisseria gonorrhoeae failing treatment with ceftriaxone and doxycycline in France, November 2017

• Published in: Euro surveillance : bulletin européen sur les maladies transmissibles Vol. 23; no. 21; p. 1
• Main Authors: Poncin, Thibault, Fouere, Sebastien, Braille, Aymeric, Camelena, Francois, Agsous, Myriem, Bebear, Cecile, Kumanski, Sylvain, Lot, Florence, Mercier-Delarue, Severine, Ngangro, Ndeindo Ndeikoundam, Salmona, Maud, Schnepf, Nathalie, Timsit, Julie, Unemo, Magnus, Bercot, Beatrice
• Format: Journal Article
• Language: English
• Published: Sweden Centre Europeen pour la Surveillance Epidemiologique du SIDA (European Centre for the Epidemiological Monitoring of AIDS) 24.05.2018; European Centre for Disease Prevention and Control; European Centre for Disease Prevention and Control (ECDC)
• Subjects: Antibiotics; Drug resistance; Genetics; Gonorrhea; Human genetics; Human health and pathology; Infectious diseases; Life Sciences; Multidrug resistant organisms; Rapid Communication; France; gonorrhoea; diagnosis; antimicrobial resistance; treatment failure; antimicrobial treatment
• ISSN: 1560-7917; 1025-496X; 1560-7917; 1025-496X
• DOI: 10.2807/1560-7917.ES.2018.23.21.1800264

We report a multidrug-resistant Neisseria gonorrhoeae urogenital and pharyngeal infection with ceftriaxone resistance and intermediate resistance to azithromycin in a heterosexual woman in her 20s in France. Treatment with ceftriaxone plus doxycycline failed for the pharyngeal localisation. Whole-genome sequencing of isolate F90 identified MLST 1903 , NG-MAST ST 3435 , NG-STAR 233 , and relevant resistance determinants. F90 showed phenotypic and genotypic similarities to an internationally spreading multidrug-resistant and ceftriaxone-resistant clone detected in Japan and subsequently in Australia, Canada and Denmark.