Non-Sex Cord-Stromal Ovarian Tumors Frequently Produce and Secrete Estrogen in Postmenopausal Women: Impact on Bone Metabolism and Abnormal Endometrial Histology

Objective:We investigated whether the estrogen released from non-sex cord-stromal ovarian tumors has biological effects on bone and endometrial tissue in postmenopausal women.Materials and Methods:A total of 132 patients with malignant (n = 112) or benign (n = 20) gynecological disease with normal p...

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Published inThe journal of clinical endocrinology and metabolism Vol. 98; no. 7; pp. 2775 - 2782
Main Authors Matsumura, Sohei, Ohta, Tsuyoshi, Takahashi, Toshifumi, Yamazaki, Takeshi, Takahashi, Kazuhiro, Kurachi, Hirohisa
Format Journal Article
LanguageEnglish
Published Bethesda, MD Oxford University Press 01.07.2013
Endocrine Society
Subjects
Sex
Sex
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ISSN0021-972X
1945-7197
1945-7197
DOI10.1210/jc.2013-1267

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Summary:Objective:We investigated whether the estrogen released from non-sex cord-stromal ovarian tumors has biological effects on bone and endometrial tissue in postmenopausal women.Materials and Methods:A total of 132 patients with malignant (n = 112) or benign (n = 20) gynecological disease with normal postmenopausal ovaries were recruited as a control group (group C). The 75 patients with ovarian tumors were divided into 2 groups: group L (serum estradiol [E2] level of < 20 pg/ml; n = 42) and group H (serum E2 level of > 20 pg/ml; n = 33). The subjects' serum E2 levels, bone mineral density, urinary levels of the N-telopeptide of type I collagen, and serum levels of bone-specific alkaline phosphatase were measured before and after surgery. Histological examinations of the endometrium were carried out in the 75 patients with non-sex cord-stromal ovarian tumors.Results:High serum E2 levels were detected in 33 (44%) of 75 patients with ovarian tumors. The serum E2 levels of group H were significantly decreased after surgery. In the other subjects, there were no significant differences between the serum E2 levels observed before and after surgery. The mean preoperative N-telopeptide of type I collagen and bone-specific alkaline phosphatase levels of group H were significantly lower than those of group C. The bone mineral density values of groups L and H were significantly decreased after surgery. Five (6.7%) of 75 patients with non-sex cord-stromal ovarian tumors displayed abnormal endometrial histology, including 4 patients with grade 1 endometrioid cancer.Conclusions:The E2 released from ovarian tumors might have biological effects on bone metabolism and the incidence of abnormal endometrial histology.
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ISSN:0021-972X
1945-7197
1945-7197
DOI:10.1210/jc.2013-1267