Stage-dependent role of interhemispheric pathway for motor recovery in primates

• Published in: Nature communications Vol. 15; no. 1; pp. 6762 - 14
• Main Authors: Mitsuhashi, Masahiro, Yamaguchi, Reona, Kawasaki, Toshinari, Ueno, Satoko, Sun, Yiping, Isa, Kaoru, Takahashi, Jun, Kobayashi, Kenta, Onoe, Hirotaka, Takahashi, Ryosuke, Isa, Tadashi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.08.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 14/1; 42/35; 42/44; 631/378/1687/1825; 631/378/1697/2602; 631/378/2632/1663; 631/378/2632/2635; 82/51; Animals; Cerebral hemispheres; Cortex (motor); Cortex (premotor); Dextrous hands; Electrocorticography; Female; Functional Laterality - physiology; Hand - physiology; Humanities and Social Sciences; Low frequencies; Male; Motor Cortex - physiology; Movement - physiology; multidisciplinary; Pyramidal tracts; Pyramidal Tracts - physiology; Recovery; Recovery (Medical); Recovery of Function - physiology; Science; Science (multidisciplinary); Sensorimotor Cortex - physiology; Somatosensory cortex; Spinal Cord Injuries - physiopathology; Therapeutic targets
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-024-51070-w

Whether and how the non-lesional sensorimotor cortex is activated and contributes to post-injury motor recovery is controversial. Here, we investigated the role of interhemispheric pathway from the contralesional to ipsilesional premotor cortex in activating the ipsilesional sensorimotor cortex and promoting recovery after lesioning the lateral corticospinal tract at the cervical cord, by unidirectional chemogenetic blockade in macaques. The blockade impaired dexterous hand movements during the early recovery stage. Electrocorticographical recording showed that the low frequency band activity of the ipsilesional premotor cortex around movement onset was decreased by the blockade during the early recovery stage, while it was increased by blockade during the intact state and late recovery stage. These results demonstrate that action of the interhemispheric pathway changed from inhibition to facilitation, to involve the ipsilesional sensorimotor cortex in hand movements during the early recovery stage. The present study offers insights into the stage-dependent role of the interhemispheric pathway and a therapeutic target in the early recovery stage after lesioning of the corticospinal tract. Whether and how the non-lesional sensorimotor cortex contributes to the post-injury recovery are not fully understood. The authors, show that the interhemispheric pathway between the premotor cortices contributed to hand movements in early recovery after damage to the corticospinal tract in primates.