Next Generation Sequencing of Acute Myeloid Leukemia: Influencing Prognosis

Acute myeloid leukemia (AML) is a clonal disorder of the blood forming cells characterized by accumulation of immature blast cells in the bone marrow and peripheral blood. Being a heterogeneous disease, AML has been the subject of numerous studies that focus on unraveling the clinical, cellular and...

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Published inBMC genomics Vol. 16; no. Suppl 1; p. S5
Main Authors Ilyas, Asad Muhammad, Ahmad, Sultan, Faheem, Muhammad, Naseer, Muhammad Imran, Kumosani, Taha A, Al-Qahtani, Muhammad Hussain, Gari, Mamdooh, Ahmed, Farid
Format Journal Article
LanguageEnglish
Published London BioMed Central 15.01.2015
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ISSN1471-2164
1471-2164
DOI10.1186/1471-2164-16-S1-S5

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Summary:Acute myeloid leukemia (AML) is a clonal disorder of the blood forming cells characterized by accumulation of immature blast cells in the bone marrow and peripheral blood. Being a heterogeneous disease, AML has been the subject of numerous studies that focus on unraveling the clinical, cellular and molecular variations with the aim to better understand and treat the disease. Cytogenetic-risk stratification of AML is well established and commonly used by clinicians in therapeutic management of cases with chromosomal abnormalities. Successive inclusion of novel molecular abnormalities has substantially modified the classification and understanding of AML in the past decade. With the advent of next generation sequencing (NGS) technologies the discovery of novel molecular abnormalities has accelerated. NGS has been successfully used in several studies and has provided an unprecedented overview of molecular aberrations as well as the underlying clonal evolution in AML. The extended spectrum of abnormalities discovered by NGS is currently under extensive validation for their prognostic and therapeutic values. In this review we highlight the recent advances in the understanding of AML in the NGS era.
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ISSN:1471-2164
1471-2164
DOI:10.1186/1471-2164-16-S1-S5