A genetic algorithm for the detection of new cis-regulatory modules in sets of coregulated genes

• Published in: Bioinformatics Vol. 20; no. 12; pp. 1974 - 1976
• Main Authors: Aerts, Stein, Van Loo, Peter, Moreau, Yves, De Moor, Bart
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 12.08.2004; Oxford Publishing Limited (England)
• Subjects: Algorithms; Biological and medical sciences; Chromosome Mapping - methods; Fundamental and applied biological sciences. Psychology; Gene Expression Profiling - methods; Gene Expression Regulation - genetics; General aspects; Genes, Regulator - genetics; Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects); Models, Genetic; Sequence Alignment - methods; Sequence Analysis, DNA - methods; Software; Genetics; Gene; Detection; Genetic algorithm; Bioinformatics
• ISSN: 1367-4803; 1367-4811; 1460-2059; 1367-4811
• DOI: 10.1093/bioinformatics/bth179

The implementation of a genetic algorithm is described that provides a fast method of searching for the optimal combination of transcription factor binding sites in a set of regulatory sequences. Availability: The algorithm can be used transparently as a web service from within the Toucan software. Toucan can be accessed at http://www.esat.kuleuven.ac.be/~saerts/software/toucan.php. A standalone version of the software is available upon request.