Platelet adhesion on silicon modified hydrogenated amorphous carbon films

• Published in: Biomaterials Vol. 25; no. 2; pp. 239 - 245
• Main Authors: Okpalugo, T.I.T., Ogwu, A.A., Maguire, P.D., McLaughlin, J.A.D.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 2004
• Subjects: Biocompatible Materials - chemistry; Blood Platelets - physiology; Carbon - chemistry; Cell Adhesion - physiology; Contact angle/surface energy; Haemocompatibility; Human platelet aggregation; Humans; Raman spectroscopy; Si-DLC; Silicon - chemistry; Spectrum Analysis, Raman; Temperature; Work function/semi-conduction; Si-DLC; Contact angle/surface energy; Raman spectroscopy; Work function/semi-conduction; Human platelet aggregation; Haemocompatibility
• ISSN: 0142-9612; 1878-5905
• DOI: 10.1016/S0142-9612(03)00494-0

We have investigated the effect of changes in microstructure, surface energy, surface charge condition and electronic conduction on the interaction of human platelets with silicon modified hydrogenated amorphous carbon films (a-C:H:Si or Si-DLC). Results based on Raman spectroscopy, Scanning electron microscopy, X-ray photo-electron spectroscopy, surface energy measurements, electrical resistivity, contact potential difference, and thermal annealing indicates a correlation between some of the measured values and the interaction of the films with human blood platelets. Statistical analysis of platelet aggregation on the films using the Student's t-test indicated differences between platelet aggregation on the modified films compared to the as-deposited film at a p-value of <0.05.