Beneficial effect of low-glycemic index diet in overweight NIDDM subjects

• Published in: Diabetes care Vol. 15; no. 4; pp. 562 - 564
• Main Authors: Wolever, T.M.S. (University of Toronto, Toronto, Ontario, Canada), Jenkins, D.J.A, Vuksan, V, Jenkins, A.L, Wong, G.S, Josse, R.G
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.04.1992
• Subjects: blood; blood glucose; Blood Glucose - metabolism; blood plasma; CARBOHIDRATOS; CHOLESTEROL; Cholesterol - blood; Cholesterol, HDL; Cholesterol, HDL - blood; Cholesterol, LDL; Cholesterol, LDL - blood; COLESTEROL; CORPS GRAS; DIABETE; DIABETES; Diabetes Mellitus; Diabetes Mellitus - diet therapy; Diabetes Mellitus - physiopathology; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - diet therapy; Diabetes Mellitus, Type 2 - physiopathology; diet; diet therapy; Diet, Diabetic; Diet, Reducing; DIETA; dietary carbohydrate; Dietary Carbohydrates; dietary fat; dietary fiber; Female; FEMME; FIBRA DE LA DIETA; FIBRE ALIMENTAIRE; Fructosamine; GLICEMIA; GLUCIDE; GLYCEMIE; GRASAS; Hexosamines; Hexosamines - blood; HOMBRES; HOMME; Humans; Male; men; metabolism; Middle Aged; MUJERES; noninsulin-dependent diabetes mellitus; Obesity; overweight; physiopathology; PLASMA SANGUIN; PLASMA SANGUINEO; REGIME ALIMENTAIRE; SOBREPESO; SURPOIDS; Triglycerides; Triglycerides - blood; Weight Loss; women
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/diacare.15.4.562

Beneficial effect of low-glycemic index diet in overweight NIDDM subjects. T M Wolever , D J Jenkins , V Vuksan , A L Jenkins , G S Wong and R G Josse Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada. Abstract OBJECTIVE--To determine whether low-glycemic index (GI) diets have clinical utility in overweight patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS--Six patients with NIDDM were studied on both high- and low-GI diets of 6-wk duration with metabolic diets with a randomized crossover design. Both diets were of similar composition (57% carbohydrate, 23% fat, and 34 g/day dietary fiber), but the low-GI diet had a GI of 58 compared with 86 for the high-GI diet. RESULTS--Small and similar amounts of weight were lost on both diets: 2.5 kg on high-GI diet and 1.8 kg on low-GI diet. On the low-GI diet, the mean level of serum fructosamine, as an index of overall blood glucose control, was lower than on the high-GI diet by 8% (P less than 0.05), and total serum cholesterol was lower by 7% (P less than 0.01). CONCLUSIONS--In overweight patients with NIDDM, reducing diet GI improves overall blood glucose and lipid control.