A rare goblet cell adenocarcinoma arising from Barrett’s esophagus: the first reported case in the esophagus

• Published in: Journal of pathology and translational medicine Vol. 58; no. 2; pp. 81 - 86
• Main Authors: Oh, Chi Eun, Kim, Sung Eun, Oh, Sun-Ju
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Society of Pathologists, Korean Society for Cytopathology 01.03.2024; The Korean Society of Pathologists/The Korean Society for Cytopathology; Korean Society of Pathologists & the Korean Society for Cytopathology; 대한병리학회
• Subjects: Biopsy; Cancer; Case reports; Case Study; Chemotherapy; Cytokeratin; Digestive system; Esophagus; extra-appendiceal; goblet cell adenocarcinoma; goblet cell carcinoid; Lymphatic system; Metastasis; Morphology; Neuroendocrine tumors; Small intestine; Stains & staining; Stem cells; Stomach; Tomography; Ulcers; 병리학; Goblet cell carcinoid; Goblet cell adenocarcinoma; Extra-appendiceal
• ISSN: 2383-7837; 2383-7845
• DOI: 10.4132/jptm.2023.12.26

Goblet cell adenocarcinoma (GCA) is a rare and distinctive amphicrine tumor comprised of goblet-like mucinous cells and neuroendocrine cells. It is believed to originate from pluripotent stem cells located at the base of crypts. GCA predominantly arises from the appendix, with a few reported cases in extra-appendiceal locations such as the colorectum, small intestine, and stomach. In this case report, we present a unique instance of a 64-year-old male who initially received a diagnosis of neuroendocrine carcinoma in the distal esophagus based on biopsy but, following resection, was subsequently re-diagnosed with GCA arising from Barrett’s esophagus.