Impact of Female Gender in Inflammatory Bowel Diseases: A Narrative Review

Inflammatory bowel diseases show a gender bias, as reported for several other immune-mediated diseases. Female-specific differences influence disease presentation and activity, leading to a different progression between males and females. Women show a genetic predisposition to develop inflammatory b...

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Published inJournal of personalized medicine Vol. 13; no. 2; p. 165
Main Authors Lungaro, Lisa, Costanzini, Anna, Manza, Francesca, Barbalinardo, Marianna, Gentili, Denis, Guarino, Matteo, Caputo, Fabio, Zoli, Giorgio, De Giorgio, Roberto, Caio, Giacomo
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 17.01.2023
MDPI
Subjects
Age
Cholangitis
Development and progression
Epidemiology
Females
Gender
Genotype & phenotype
Immune system
Inflammatory bowel disease
Inflammatory bowel diseases
Intestine
Investigations
Males
Pain perception
Pathogenesis
Patient compliance
Patients
Polymorphism
Precision medicine
Quality of life
Review
Sex discrimination
Surgery
Womens health
X chromosomes
female gender
female sex
ulcerative colitis
quality of life
inflammatory bowel disease
Crohn’s disease
women
Online AccessGet full text
ISSN2075-4426
2075-4426
DOI10.3390/jpm13020165

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Abstract Inflammatory bowel diseases show a gender bias, as reported for several other immune-mediated diseases. Female-specific differences influence disease presentation and activity, leading to a different progression between males and females. Women show a genetic predisposition to develop inflammatory bowel disease related to the X chromosome. Female hormone fluctuation influences gastrointestinal symptoms, pain perception, and the state of active disease at the time of conception could negatively affect the pregnancy. Women with inflammatory bowel disease report a worse quality of life, higher psychological distress, and reduced sexual activity than male patients. This narrative review aims to resume the current knowledge of female-related features in clinical manifestations, development, and therapy, as well as sexual and psychological implications related to inflammatory bowel disease. The final attempt is to provide gastroenterologists with a roadmap of female-specific differences, to improve patients’ diagnosis, management, and treatment.
AbstractList Inflammatory bowel diseases show a gender bias, as reported for several other immune-mediated diseases. Female-specific differences influence disease presentation and activity, leading to a different progression between males and females. Women show a genetic predisposition to develop inflammatory bowel disease related to the X chromosome. Female hormone fluctuation influences gastrointestinal symptoms, pain perception, and the state of active disease at the time of conception could negatively affect the pregnancy. Women with inflammatory bowel disease report a worse quality of life, higher psychological distress, and reduced sexual activity than male patients. This narrative review aims to resume the current knowledge of female-related features in clinical manifestations, development, and therapy, as well as sexual and psychological implications related to inflammatory bowel disease. The final attempt is to provide gastroenterologists with a roadmap of female-specific differences, to improve patients' diagnosis, management, and treatment.Inflammatory bowel diseases show a gender bias, as reported for several other immune-mediated diseases. Female-specific differences influence disease presentation and activity, leading to a different progression between males and females. Women show a genetic predisposition to develop inflammatory bowel disease related to the X chromosome. Female hormone fluctuation influences gastrointestinal symptoms, pain perception, and the state of active disease at the time of conception could negatively affect the pregnancy. Women with inflammatory bowel disease report a worse quality of life, higher psychological distress, and reduced sexual activity than male patients. This narrative review aims to resume the current knowledge of female-related features in clinical manifestations, development, and therapy, as well as sexual and psychological implications related to inflammatory bowel disease. The final attempt is to provide gastroenterologists with a roadmap of female-specific differences, to improve patients' diagnosis, management, and treatment.
Inflammatory bowel diseases show a gender bias, as reported for several other immune-mediated diseases. Female-specific differences influence disease presentation and activity, leading to a different progression between males and females. Women show a genetic predisposition to develop inflammatory bowel disease related to the X chromosome. Female hormone fluctuation influences gastrointestinal symptoms, pain perception, and the state of active disease at the time of conception could negatively affect the pregnancy. Women with inflammatory bowel disease report a worse quality of life, higher psychological distress, and reduced sexual activity than male patients. This narrative review aims to resume the current knowledge of female-related features in clinical manifestations, development, and therapy, as well as sexual and psychological implications related to inflammatory bowel disease. The final attempt is to provide gastroenterologists with a roadmap of female-specific differences, to improve patients' diagnosis, management, and treatment.
Audience Academic
Author Lungaro, Lisa
Caio, Giacomo
Zoli, Giorgio
Barbalinardo, Marianna
Guarino, Matteo
Costanzini, Anna
De Giorgio, Roberto
Caputo, Fabio
Manza, Francesca
Gentili, Denis
AuthorAffiliation 5 Mucosal Immunology and Biology Research Center, Massachusetts General Hospital-Harvard Medical School, Boston, MA 02114, USA
3 Department of Internal Medicine, SS Annunziata Hospital, Cento, University of Ferrara, 44042 Ferrara, Italy
4 Centre for the Study and Treatment of Alcohol-Related Diseases, Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy
1 Department of Translational Medicine, St. Anna Hospital, University of Ferrara, 44124 Ferrara, Italy
2 National Research Council, Institute for the Study of Nanostructured Materials (CNR-ISMN), Via P. Gobetti 101, 40129 Bologna, Italy
AuthorAffiliation_xml – name: 2 National Research Council, Institute for the Study of Nanostructured Materials (CNR-ISMN), Via P. Gobetti 101, 40129 Bologna, Italy
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– name: 5 Mucosal Immunology and Biology Research Center, Massachusetts General Hospital-Harvard Medical School, Boston, MA 02114, USA
– name: 1 Department of Translational Medicine, St. Anna Hospital, University of Ferrara, 44124 Ferrara, Italy
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  surname: Caio
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Issue 2
Keywords female gender
female sex
ulcerative colitis
quality of life
inflammatory bowel disease
Crohn’s disease
women
Language English
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These authors contributed equally to this work.
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Snippet Inflammatory bowel diseases show a gender bias, as reported for several other immune-mediated diseases. Female-specific differences influence disease...
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SubjectTerms Age
Cholangitis
Development and progression
Epidemiology
Females
Gender
Genotype & phenotype
Immune system
Inflammatory bowel disease
Inflammatory bowel diseases
Intestine
Investigations
Males
Pain perception
Pathogenesis
Patient compliance
Patients
Polymorphism
Precision medicine
Quality of life
Review
Sex discrimination
Surgery
Womens health
X chromosomes
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Title Impact of Female Gender in Inflammatory Bowel Diseases: A Narrative Review
URI https://www.ncbi.nlm.nih.gov/pubmed/36836400
https://www.proquest.com/docview/2908297804
https://www.proquest.com/docview/2780082691
https://pubmed.ncbi.nlm.nih.gov/PMC9958616
Volume 13
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