A New Sensitive Derivatization Reagent for Liquid Chromatographic Separation of Hydroxyl Compounds
A new sensitive derivatization reagent for use in liquid chromatographic separation of hydroxyl compounds has been developed. A suitable reagent for this purpose, 4-dimethylamino-1-naphthoyl nitrile, was readily prepared from the corresponding acid chloride by the exchange reaction with trimethylsil...
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| Published in | Chemical & pharmaceutical bulletin Vol. 29; no. 3; pp. 899 - 901 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Tokyo
The Pharmaceutical Society of Japan
01.01.1981
Japan Science and Technology Agency |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0009-2363 1347-5223 1347-5223 |
| DOI | 10.1248/cpb.29.899 |
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| Abstract | A new sensitive derivatization reagent for use in liquid chromatographic separation of hydroxyl compounds has been developed. A suitable reagent for this purpose, 4-dimethylamino-1-naphthoyl nitrile, was readily prepared from the corresponding acid chloride by the exchange reaction with trimethylsilyl cyanide. Condensation of a hydroxyl compound with the reagent was effected in the presence of triethylamine under the mild condition. The resulting ester was highly responsible for a fluorescence detector with a detection limit of 200 pg. |
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| AbstractList | A new sensitive derivatization reagent for use in liquid chromatographic separation of hydroxyl compounds has been developed. A suitable reagent for this purpose, 4-dimethylamino-1-naphthoyl nitrile, was readily prepared from the corresponding acid chloride by the exchange reaction with trimethylsilyl cyanide. Condensation of a hydroxyl compound with the reagent was effected in the presence of triethylamine under the mild condition. The resulting ester was highly responsible for a fluorescence detector with a detection limit of 200 pg. |
| Author | NAMBARA, TOSHIO GOTO, JUNICHI GOTO, NOBUHARU KOMATSU, SAKAE |
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| References | 1) M.S.F. Ross, J. Chromatogr., 141, 107 (1977), and references quoted therein. 7) J. Goto, H. Kato, F. Hasegawa, and T. Nambara, Chem. Pharm. Bull., 27, 1402 (1979). 4) J. Goto, N. Goto, A. Hikichi, T. Nishimaki, and T. Nambara, Anal. Chim. Acta, 120, 187 (1980). 3) N. Nimura and T. Kinoshita, Anal. Lett., 13, 191 (1980). 5) K.E. Koenig and W.P. Weber, Tetrahedron Lett., 1974, 2275. 6) A. Fischer, H.M. Fountain, and J. Vaughan, J. Chem. Soc., 1959, 1310. 2) T. Kawasaki, M. Maeda, and A. Tsuji, J. Chromatogr., 163, 143 (1979). |
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| Title | A New Sensitive Derivatization Reagent for Liquid Chromatographic Separation of Hydroxyl Compounds |
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