A New Sensitive Derivatization Reagent for Liquid Chromatographic Separation of Hydroxyl Compounds

A new sensitive derivatization reagent for use in liquid chromatographic separation of hydroxyl compounds has been developed. A suitable reagent for this purpose, 4-dimethylamino-1-naphthoyl nitrile, was readily prepared from the corresponding acid chloride by the exchange reaction with trimethylsil...

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Published inChemical & pharmaceutical bulletin Vol. 29; no. 3; pp. 899 - 901
Main Authors GOTO, JUNICHI, GOTO, NOBUHARU, NAMBARA, TOSHIO, KOMATSU, SAKAE
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 01.01.1981
Japan Science and Technology Agency
Subjects
4-dimethylamino-1-naphthoyl nitrile
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ISSN0009-2363
1347-5223
1347-5223
DOI10.1248/cpb.29.899

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Summary:A new sensitive derivatization reagent for use in liquid chromatographic separation of hydroxyl compounds has been developed. A suitable reagent for this purpose, 4-dimethylamino-1-naphthoyl nitrile, was readily prepared from the corresponding acid chloride by the exchange reaction with trimethylsilyl cyanide. Condensation of a hydroxyl compound with the reagent was effected in the presence of triethylamine under the mild condition. The resulting ester was highly responsible for a fluorescence detector with a detection limit of 200 pg.
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ISSN:0009-2363
1347-5223
1347-5223
DOI:10.1248/cpb.29.899