Nanoarchitectured Structure and Surface Biofunctionality of Mesoporous Silica Nanoparticles

Mesoporous silica nanoparticles (MSNs), one of the important porous materials, have garnered interest owing to their highly attractive physicochemical features and advantageous morphological attributes. They are of particular importance for use in diverse fields including, but not limited to, adsorp...

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Published inAdvanced materials (Weinheim) Vol. 32; no. 23; pp. e1907035 - n/a
Main Authors Kankala, Ranjith Kumar, Han, Ya‐Hui, Na, Jongbeom, Lee, Chia‐Hung, Sun, Ziqi, Wang, Shi‐Bin, Kimura, Tatsuo, Ok, Yong Sik, Yamauchi, Yusuke, Chen, Ai‐Zheng, Wu, Kevin C.‐W.
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 01.06.2020
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ISSN0935-9648
1521-4095
1521-4095
DOI10.1002/adma.201907035

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Summary:Mesoporous silica nanoparticles (MSNs), one of the important porous materials, have garnered interest owing to their highly attractive physicochemical features and advantageous morphological attributes. They are of particular importance for use in diverse fields including, but not limited to, adsorption, catalysis, and medicine. Despite their intrinsic stable siliceous frameworks, excellent mechanical strength, and optimal morphological attributes, pristine MSNs suffer from poor drug loading efficiency, as well as compatibility and degradability issues for therapeutic, diagnostic, and tissue engineering purposes. Collectively, the desirable and beneficial properties of MSNs have been harnessed by modifying the surface of the siliceous frameworks through incorporating supramolecular assemblies and various metal species, and through incorporating supramolecular assemblies and various metal species and their conjugates. Substantial advancements of these innovative colloidal inorganic nanocontainers drive researchers in promoting them toward innovative applications like stimuli (light/ultrasound/magnetic)‐responsive delivery‐associated therapies with exceptional performance in vivo. Here, a brief overview of the fabrication of siliceous frameworks, along with discussions on the significant advances in engineering of MSNs, is provided. The scope of the advancement in terms of structural and physicochemical attributes and their effects on biomedical applications with a particular focus on recent studies is emphasized. Finally, interesting perspectives are recapitulated, along with the scope toward clinical translation. Mesoporous silica nanoparticles (MSNs) have garnered enormous interest owing to their highly advantageous physicochemical and morphological attributes. Collectively, progression has been made by modifying the surface of the siliceous frameworks through incorporating diverse supramolecular assemblies. An overview of the fabrication of MSNs and discussions on significant advances in engineering of MSNs, along with their scope toward clinical translation, is provided.
Bibliography:This article is dedicated to Dr. Victor S.‐Y. Lin, who was a professor of chemistry at Iowa State University from 1999 until he unexpectedly passed away in 2010. Victor was a pioneer in the synthesis and applications of mesoporous silica nanoparticles (MSNs), a term he created to describe nanometer‐sized mesoporous silica materials with well‐defined and controllable properties in the biomedical and catalytic applications.
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ISSN:0935-9648
1521-4095
1521-4095
DOI:10.1002/adma.201907035