CIRCULATORY EFFECTS OF ORAL AND SUBCUTANEOUS ADMINISTRATION IN NORMAL SUBJECTS OF A NEW BRONCHODILATOR, IBUTEROL, A PRO‐DRUG TO TERBUTALINE

1 The di‐isobutyryl ester of terbutaline, ibuterol, was given subcutaneously and orally to healthy volunteers and its effects on heart rate, arterial blood pressure, and ECG were compared with those of terbutaline itself. The effects of the two substances were qualitatively identical, but quantitati...

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Bibliographic Details
Published inBritish journal of pharmacology Vol. 58; no. 1; pp. 43 - 46
Main Authors HÖGLUND, ELIN, WESTLING, H., WHITE, T.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.09.1976
Subjects
Administration, Oral
Blood Pressure - drug effects
Butyrates - administration & dosage
Butyrates - pharmacology
Electrocardiography
Heart Rate - drug effects
Hemodynamics - drug effects
Humans
Injections, Subcutaneous
Male
Muscles - blood supply
Regional Blood Flow - drug effects
Terbutaline - administration & dosage
Terbutaline - analogs & derivatives
Terbutaline - pharmacology
Time Factors
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ISSN0007-1188
1476-5381
DOI10.1111/j.1476-5381.1976.tb07691.x

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Summary:1 The di‐isobutyryl ester of terbutaline, ibuterol, was given subcutaneously and orally to healthy volunteers and its effects on heart rate, arterial blood pressure, and ECG were compared with those of terbutaline itself. The effects of the two substances were qualitatively identical, but quantitatively different. 2 By mouth, ibuterol acted more rapidly, and was 2–3 times more active. After intramuscular injection, ibuterol caused less increase in local blood flow than terbutaline. 3 Ibuterol can be regarded as a pro‐drug, which in itself has little activity, but which can be made active in the body.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1976.tb07691.x