AI-based lumbar central canal stenosis classification on sagittal MR images is comparable to experienced radiologists using axial images

• Published in: European radiology Vol. 35; no. 4; pp. 2298 - 2306
• Main Authors: van der Graaf, Jasper W., Brundel, Liron, van Hooff, Miranda L., de Kleuver, Marinus, Lessmann, Nikolas, Maresch, Bas J., Vestering, Myrthe M., Spermon, Jacco, van Ginneken, Bram, Rutten, Matthieu J. C. M.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2025; Springer Nature B.V
• Subjects: Adult; Aged; Algorithms; Artificial Intelligence; Back pain; Canals (anatomy); Classification; Deep learning; Diagnostic Radiology; Female; Humans; Image Interpretation, Computer-Assisted - methods; Imaging; Internal Medicine; Interventional Radiology; Intervertebral discs; Low back pain; Lumbar Vertebrae - diagnostic imaging; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Masks; Medical imaging; Medicine; Medicine & Public Health; Metastasis; Middle Aged; Musculoskeletal; Neural networks; Neuroradiology; Pain; Patients; Radiologists; Radiology; Reproducibility of Results; Sensitivity; Sensitivity and Specificity; Spinal Stenosis - classification; Spinal Stenosis - diagnostic imaging; Stenosis; Ultrasound; Vertebrae; Deep learning; Spine; MRI; Lumbar central canal stenosis; Machine learning
• ISSN: 1432-1084; 0938-7994; 1432-1084
• DOI: 10.1007/s00330-024-11080-0

Objectives The assessment of lumbar central canal stenosis (LCCS) is crucial for diagnosing and planning treatment for patients with low back pain and neurogenic pain. However, manual assessment methods are time-consuming, variable, and require axial MRIs. The aim of this study is to develop and validate an AI-based model that automatically classifies LCCS using sagittal T2-weighted MRIs. Methods A pre-existing 3D AI algorithm was utilized to segment the spinal canal and intervertebral discs (IVDs), enabling quantitative measurements at each IVD level. Four musculoskeletal radiologists graded 683 IVD levels from 186 LCCS patients using the 4-class Lee grading system. A second consensus reading was conducted by readers 1 and 2, which, along with automatic measurements, formed the training dataset for a multiclass (grade 0–3) and binary (grade 0–1 vs. 2–3) random forest classifier with tenfold cross-validation. Results The multiclass model achieved a Cohen’s weighted kappa of 0.86 (95% CI: 0.82–0.90), comparable to readers 3 and 4 with 0.85 (95% CI: 0.80–0.89) and 0.73 (95% CI: 0.68–0.79) respectively. The binary model demonstrated an AUC of 0.98 (95% CI: 0.97–0.99), sensitivity of 93% (95% CI: 91–96%), and specificity of 91% (95% CI: 87–95%). In comparison, readers 3 and 4 achieved a specificity of 98 and 99% and sensitivity of 74 and 54%, respectively. Conclusion Both the multiclass and binary models, while only using sagittal MR images, perform on par with experienced radiologists who also had access to axial sequences. This underscores the potential of this novel algorithm in enhancing diagnostic accuracy and efficiency in medical imaging. Key Points Question How can the classification of lumbar central canal stenosis (LCCS) be made more efficient? Findings Multiclass and binary AI models, using only sagittal MR images, performed on par with experienced radiologists who also had access to axial sequences. Clinical relevance Our AI algorithm accurately classifies LCCS from sagittal MRI, matching experienced radiologists. This study offers a promising tool for automated LCCS assessment from sagittal T2 MRI, potentially reducing the reliance on additional axial imaging .