Effects of geometric individualisation of a human spine model on load sharing: neuro-musculoskeletal simulation reveals significant differences in ligament and muscle contribution

• Published in: Biomechanics and modeling in mechanobiology Vol. 22; no. 2; pp. 669 - 694
• Main Authors: Meszaros-Beller, Laura, Hammer, Maria, Riede, Julia M., Pivonka, Peter, Little, J. Paige, Schmitt, Syn
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2023; Springer Nature B.V
• Subjects: Biological and Medical Physics; Biomechanical Phenomena; Biomechanics; Biomedical Engineering and Bioengineering; Biophysics; Bones; Computed tomography; Datasets; Engineering; Finite Element Analysis; Geometry; Gravity; Humans; Internal forces; Intervertebral Disc - physiology; Intervertebral discs; Ligaments; Ligaments - physiology; Load; Load distribution; Load distribution (forces); Load sharing; Lumbar Vertebrae - physiology; Models, Biological; Multibody systems; Muscles; Muscles - physiology; Original Paper; Rigid-body dynamics; Rotation; Simulation; Spine; Stiffness; Theoretical and Applied Mechanics; Tomography; Vertebrae; Weight-Bearing - physiology; Spine biomechanics; Forward-dynamics; Musculoskeletal modelling; Subject-specific; Load sharing
• ISSN: 1617-7959; 1617-7940; 1617-7940
• DOI: 10.1007/s10237-022-01673-3

In spine research, two possibilities to generate models exist: generic (population-based) models representing the average human and subject-specific representations of individuals. Despite the increasing interest in subject specificity, individualisation of spine models remains challenging. Neuro-musculoskeletal (NMS) models enable the analysis and prediction of dynamic motions by incorporating active muscles attaching to bones that are connected using articulating joints under the assumption of rigid body dynamics. In this study, we used forward-dynamic simulations to compare a generic NMS multibody model of the thoracolumbar spine including fully articulated vertebrae, detailed musculature, passive ligaments and linear intervertebral disc (IVD) models with an individualised model to assess the contribution of individual biological structures. Individualisation was achieved by integrating skeletal geometry from computed tomography and custom-selected muscle and ligament paths. Both models underwent a gravitational settling process and a forward flexion-to-extension movement. The model-specific load distribution in an equilibrated upright position and local stiffness in the L4/5 functional spinal unit (FSU) is compared. Load sharing between occurring internal forces generated by individual biological structures and their contribution to the FSU stiffness was computed. The main finding of our simulations is an apparent shift in load sharing with individualisation from an equally distributed element contribution of IVD, ligaments and muscles in the generic spine model to a predominant muscle contribution in the individualised model depending on the analysed spine level.