The intersection of sleep and synaptic translation in synaptic plasticity deficits in neurodevelopmental disorders

• Published in: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology Vol. 194; no. 3; pp. 253 - 263
• Main Authors: Coulson, Rochelle L., Mourrain, Philippe, Wang, Gordon X.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2024; Springer Nature B.V
• Subjects: Animal Physiology; Animals; Behavioral plasticity; Biochemistry; Biomedical and Life Sciences; Biomedicine; Circadian rhythm; Defects; Developmental plasticity; Disorders; DNA methylation; Eukaryotic Initiation Factor-2 - metabolism; Gene expression; Human Physiology; Humans; Life Sciences; Memory; Metabolism; Nervous system; Neurodevelopmental disorders; Neurodevelopmental Disorders - etiology; Neurodevelopmental Disorders - metabolism; Neurodevelopmental Disorders - physiopathology; Neuronal Plasticity - physiology; Phenotypes; Phenotypic plasticity; Phosphorylation; Physiology; Plasticity; Protein Biosynthesis; Protein synthesis; Proteins; Proteomes; Review; Sleep; Sleep - physiology; Sleep deprivation; Synapses; Synapses - physiology; Synaptic plasticity; Synaptogenesis; Translation; Zoology; Synapse; Sleep; Neurodevelopmental disorders; Protein translation
• ISSN: 0174-1578; 1432-136X; 1432-136X
• DOI: 10.1007/s00360-023-01531-3

Individuals with neurodevelopmental disorders experience persistent sleep deficits, and there is increasing evidence that sleep dysregulation is an underlying cause, rather than merely an effect, of the synaptic and behavioral defects observed in these disorders. At the molecular level, dysregulation of the synaptic proteome is a common feature of neurodevelopmental disorders, though the mechanism connecting these molecular and behavioral phenotypes is an ongoing area of investigation. A role for eIF2α in shifting the local proteome in response to changes in the conditions at the synapse has emerged. Here, we discuss recent progress in characterizing the intersection of local synaptic translation and sleep and propose a reciprocal mechanism of dysregulation in the development of synaptic plasticity defects in neurodevelopmental disorders.