The Mechanisms of Ferroptosis Under Hypoxia

• Published in: Cellular and molecular neurobiology Vol. 43; no. 7; pp. 3329 - 3341
• Main Authors: Gao, Xin, Hu, Wei, Qian, Dianlun, Bai, Xiangfeng, He, Huilin, Li, Lin, Sun, Shibo
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2023; Springer Nature B.V
• Subjects: Apoptosis; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell death; Divalent metal transporter-1; Ferroptosis; Hypoxia-inducible factor 1; Lipid peroxidation; Neurobiology; Neurosciences; Oxidative stress; Review Paper; Signal transduction; Therapeutic targets; Hypoxia-inducible factor; Lipid peroxidation; Ferroptosis; Hypoxia; System Xc
• ISSN: 0272-4340; 1573-6830; 1573-6830
• DOI: 10.1007/s10571-023-01388-8

Ferroptosis is a new form of programmed cell death, which is characterized by the iron-dependent accumulation of lipid peroxidation and increase of ROS, resulting in oxidative stress and cell death. Iron, lipid, and multiple signaling pathways precisely control the occurrence and implementation of ferroptosis. The pathways mainly include Nrf2/HO-1 signaling pathway, p62/Keap1/Nrf2 signaling pathway. Activating p62/Keap1/Nrf2 signaling pathway inhibits ferroptosis. Nrf2/HO-1 signaling pathway promotes ferroptosis. Furthermore, some factors also participate in the occurrence of ferroptosis under hypoxia, such as HIF-1, NCOA4, DMT1. Meanwhile, ferroptosis is related with hypoxia-related diseases, such as MIRI, cancers, and AKI. Accordingly, ferroptosis appears to be a therapeutic target for hypoxia-related diseases.