Essential fatty acids, plasma cholesterol, and fat-soluble vitamins in subjects with age-related maculopathy and matched control subjects

• Published in: The American journal of clinical nutrition Vol. 57; no. 3; pp. 428 - 433
• Main Authors: Sanders, TA, Haines, AP, Wormald, R, Wright, LA, Obeid, O
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.03.1993; American Society for Clinical Nutrition; American Society for Clinical Nutrition, Inc
• Subjects: ACIDE GRAS POLYINSATURE; ACIDOS GRASOS POLIINSATURADOS; age-related maculopathy; Aged; Aging; alpha-tocopherol; analogs & derivatives; beta Carotene; beta Carotene - analogs & derivatives; Biological and medical sciences; blood; blood plasma; carotene; CAROTENOIDE; CAROTENOIDES; Carotenoids; Carotenoids - analogs & derivatives; Carotenoids - blood; CHOLESTEROL; Cholesterol - blood; COLESTEROL; Cryptoxanthins; Diet; Docosahexaenoic acid; ENFERMEDADES DE LOS OJOS; ERITROCITOS; ERYTHROCYTE; erythrocytes; eye diseases; fat soluble vitamins; Fatty Acids, Essential; Fatty Acids, Essential - blood; Female; FEMME; FOSFOLIPIDOS; gender differences; HOMBRES; HOMME; Humans; lipid peroxidation; Macula Lutea; MALADIE DE L'OEIL; Male; Medical research; Medical sciences; men; MUJERES; Nutrition; Older people; Ophthalmology; PHOSPHATIDE; phospholipids; Phospholipids - blood; PLASMA SANGUIN; PLASMA SANGUINEO; Polyunsaturated fatty acids; Retinal Diseases; Retinal Diseases - blood; RETINOL; Retinopathies; Sex Characteristics; SEXE; SEXO; Smoking; smoking (habit); Smoking - blood; Solubility; TABAC; TABACO; TOCOFEROLES; TOCOPHEROL; vitamin A; Vitamin E; Vitamin E - blood; VITAMINAS; VITAMINE; Vitamins; Vitamins - blood; women; Xanthophylls; retinol; age-related maculopathy; carotenoids; vitamin E; polyunsaturated fatty acids; smoking; carotene; Docosahexaenoic acid; lipid peroxidation; Human; Retinopathy; Carotene; Sex; Visual acuity; Lipids; α-Tocopherol; Maculopathy; Fatty acids; Cholesterol; Retinol; Eye disease; Smoker; Risk factor; Carotenoid; Elderly; Age
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/57.3.428

A matched-control study of plasma retinol, α-tocopherol, carotenoid, and cholesterol concentrations and the polyunsaturated fatty acid content of plasma and erythrocyte phospholipids was undertaken in 65 elderly patients with age-related maculopathy and 65 control subjects matched for age and sex. Despite the high statistical power of the study and large variations between subjects in the variables under consideration, no significant differences were noted between patients and control subjects. However, several statistically significant differences were noted between male and female subjects independent of their classification with maculopathy or as controls and age: plasma cholesterol, total phospholipids, α-tocopherol, and β-cryptoxanthin concentrations were higher in females than in males. The mean plasma cholesterol concentration for the upper tertile of the whole sample was 7.6 mmol/L. Plasma concentrations of total carotenoids, α-carotene, and β-carotene, but not α-tocopherol, were significantly lower in smokers than in non-smokers. The results of this study do not provide any evidence in favor of changing the dietary intake of polyunsaturated fatty acids or fat-soluble vitamins to protect against age-related maculopathy.